Department of Gastroenterology, Erzurum City Hospital, Ataturk neighborhood, Çat Yolu Street, No: 36, 25240, Erzurum, Türkiye.
Department of Medical Biochemistry, School of Medicine, Erzincan Binali Yildirim University, Başbağlar neighborhood 1429. Street No:2/1 24100, Erzincan, Türkiye.
Exp Anim. 2023 Nov 9;72(4):513-519. doi: 10.1538/expanim.22-0065. Epub 2023 Jun 19.
Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers.
花旗松素（二氢槲皮素）是一种从各种植物中分离出来的类黄酮醇，具有抗氧化作用。本研究的目的是宏观和生化研究花旗松素对阿司匹林诱导的大鼠氧化胃损伤的作用，并与法莫替丁进行比较评价。大鼠分为四组给药：健康对照组、阿司匹林组（ASG）、花旗松素+阿司匹林组（TASG）和法莫替丁+阿司匹林组（FASG）。结果表明，50mg/kg 花旗松素具有抗溃疡作用。在该剂量下，花旗松素能够使 COX-1 活性接近健康大鼠的水平，并具有适当的宏观、氧化应激/抗氧化和生化参数。基于这些结果，可以说花旗松素可能成功地用作法莫替丁的更有效替代品，法莫替丁是目前公认的阿司匹林诱导溃疡的治疗方法。
