Kalidas Sabareeswari, Sumathi Shanmugam
Department of Chemistry, SAS, VIT, Vellore, 632014, Tamilnadu, India.
Heliyon. 2023 Jun 5;9(6):e16886. doi: 10.1016/j.heliyon.2023.e16886. eCollection 2023 Jun.
The current study focuses on the incorporation of natural polymers (gelatin, silk fibre) and synthetic (polyvinyl alcohol) polymer towards the fabrication of a novel composite for bone tissue engineering. The Electrospinning method was used to fabricate the novel gelatin/polyvinyl alcohol/silk fibre scaffold. XRD, FTIR and SEM-EDAX analysis was performed to characterize the composite. The characterized composite was investigated for its physical properties (porosity and mechanical studies) and biological studies (antimicrobial activity, hemocompatibility, bioactivity). The fabricated composite showed high porosity and the highest tensile strength of 34 MPa, with elongation at a break of 35.82 for the composite. The antimicrobial activity of the composite was studied and the zone of inhibition was measured around 51 ± 0.54 for , 48 ± 0.48 for and 50 ± 0.26 for . The hemolytic % was noted around 1.36 for the composite and the bioactivity assay revealed the formation of apatite on composite surfaces.
当前的研究聚焦于将天然聚合物（明胶、丝纤维）和合成聚合物（聚乙烯醇）结合起来，用于制造一种新型的骨组织工程复合材料。采用静电纺丝法制备了新型明胶/聚乙烯醇/丝纤维支架。通过X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和扫描电子显微镜-能谱分析（SEM-EDAX）对该复合材料进行表征。对表征后的复合材料进行了物理性能（孔隙率和力学性能研究）和生物学研究（抗菌活性、血液相容性、生物活性）。所制备的复合材料显示出高孔隙率，复合材料的最高拉伸强度为34MPa，断裂伸长率为35.82。研究了该复合材料的抗菌活性，其抑菌圈直径对于[具体菌种1]约为51±0.54，对于[具体菌种2]约为48±0.48，对于[具体菌种3]约为50±0.26。该复合材料的溶血率约为1.36，生物活性测定表明复合材料表面形成了磷灰石。
