Rush Beth K, Tipton Philip W, Strongosky Audrey, Wszolek Zbigniew K
Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United States.
Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
Front Neurol. 2023 Jun 2;14:1155387. doi: 10.3389/fneur.2023.1155387. eCollection 2023.
The neuropsychological profile of CSF1R-related leukoencephalopathy (CRL) is undefined. This study defines the profile, contrasts it with that of other dementia syndromes, and highlights measures sensitive to cognitive impairment.
We administered a standardized battery of neuropsychological tests to five consecutive CRL cases.
The neuropsychological profile of CRL reflects impaired general cognitive function, processing speed, executive function, speeded visual problem solving, verbal fluency, and self-reported depression and anxiety. Confrontation naming and memory are preserved. Within cognitive domains, certain measures more frequently identified impairment than others.
CRL impairs general cognitive function, processing speed, executive function. Language and visual problem solving may be impaired if processing speed is required. Confrontation naming and memory are uniquely preserved, contrasting CRL to other dementia syndromes. Cognitive screens excluding processing speed and executive function may not detect CRL cognitive manifestations. Findings sharply define cognitive impairment of CRL and inform cognitive test selection.
集落刺激因子1受体相关白质脑病（CRL）的神经心理学特征尚不明确。本研究明确了其特征，将其与其他痴呆综合征的特征进行对比，并强调了对认知障碍敏感的测量方法。
我们对连续的5例CRL患者进行了一套标准化的神经心理学测试。
CRL的神经心理学特征反映出一般认知功能、处理速度、执行功能、快速视觉问题解决能力、语言流畅性以及自我报告的抑郁和焦虑受损。对指命名和记忆功能保留。在认知领域内，某些测量方法比其他方法更频繁地发现损伤。
CRL损害一般认知功能、处理速度、执行功能。如果需要处理速度，语言和视觉问题解决能力可能会受损。对指命名和记忆功能独特保留，这将CRL与其他痴呆综合征区分开来。排除处理速度和执行功能的认知筛查可能无法检测到CRL的认知表现。研究结果明确界定了CRL的认知障碍，并为认知测试的选择提供了依据。
