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阿久哇枣核粉对高脂血症患者身体成分、血脂谱和血压的影响:一项随机临床试验。

Effect of Ajwa date pits powder ( L.) on body composition, lipid profile and blood pressure in patients with hyperlipidemia: A randomized clinical trial.

作者信息

Nasrullah Parkha Riaz, Sehar Bismillah, Safdar Mahpara, Fatima Sadia, Zeb Falak, Shah Jahan, Ali Khan Khalil Atif, Ahmed Bilal, Alsubaie Ali Saad R, Zaman Muhammad Haidar

机构信息

Department of Human Nutrition, University of Agriculture Peshawar, KP Pakistan.

Department of Health and Social Sciences, University of Bedfordshire, UK.

出版信息

Avicenna J Phytomed. 2023 Mar-Apr;13(2):143-152. doi: 10.22038/AJP.2022.21316.

Abstract

OBJECTIVE

To evaluate the effect of Ajwa dates pit powder (ADP) on lipid profile, body composition and blood pressure in patients with hyperlipidemia.

MATERIALS AND METHODS

This randomized controlled clinical study was carried out on 40 patients with total cholesterol >200 mg/dl, triglycerides >150 mg/dl and BMI >25, of either sex, aged 30-50 years, who were recruited through written consent. The patients were divided into two groups (n=20 each): the ADP and the control group (CG). All patients received the doctor's prescribed class A statin (Rosuvastatin/ Atorvastatin) 10 mg/day, while 2.7 g ADP was given on daily basis before breakfast with lukewarm water for 40 days and the control group received the same amount of wheat flour. Body composition, blood pressure and lipid profile were determined at baseline, and after 20 and 40 days. Data were analyzed by using SPSS and GraphPad Prism.

RESULTS

ADP significantly reduced body weight (p<0.001), BMI (p<0.001), fat mass, body fat percentage, visceral fat area and waist circumference compared to the control group. Similarly, ADP significantly (p=0.000) decreased the serum level of total cholesterol and low-density lipoprotein.

CONCLUSION

ADP may have the potential to improve dyslipidemia and obesity.

摘要

目的

评估阿久哇枣核粉(ADP)对高脂血症患者血脂谱、身体成分和血压的影响。

材料与方法

本随机对照临床研究对40例总胆固醇>200mg/dl、甘油三酯>150mg/dl且BMI>25的30至50岁男女患者进行,这些患者通过书面同意招募。患者分为两组(每组n = 20):ADP组和对照组(CG)。所有患者均接受医生开的10mg/天的A类他汀类药物(瑞舒伐他汀/阿托伐他汀),而ADP组患者每天早餐前用温水服用2.7g ADP,持续40天,对照组则服用等量的小麦粉。在基线、20天和40天后测定身体成分、血压和血脂谱。数据采用SPSS和GraphPad Prism进行分析。

结果

与对照组相比,ADP显著降低了体重(p<0.001)、BMI(p<0.001)、脂肪量、体脂百分比、内脏脂肪面积和腰围。同样,ADP显著(p = 0.000)降低了血清总胆固醇和低密度脂蛋白水平。

结论

ADP可能具有改善血脂异常和肥胖的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/10274311/cf5962da4545/AJP-13-143-g001.jpg

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