Mirghani Hyder Osman, Alhowiti Amirah
Hyder Osman Mirghani Professor of Internal Medicine and Endocrine, Department of Internal Medicine, Faculty of Medicine, University of Tabuk, Saudi Arabia.
Amirah Alhowiti Assistant Professor of Family Medicine, Department of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Saudi Arabia.
Pak J Med Sci. 2025 Jan;41(1):331-337. doi: 10.12669/pjms.41.1.9928.
Dyslipidemias are major risk factors for cardiovascular disease, and other comorbidities. The focus on food and nutrition to prevent and treat cardiovascular risk factors including dyslipidemia is a paradigm shift. This is the first meta-analysis to assess the association of dates fruit and dyslipidemia in Type-2 diabetes. The study aimed to assess the same among patients with Type-2 diabetes.
Six databases were searched for relevant articles from inception to March 2024. We included randomized trials, studies with other methods, and those conducted among healthy people were excluded. A structured checklist including the author's name, country, year of publication, study type, duration of the study, lipid profile at baseline and after-dates fruit consumption, age, and gender of participants, type of dates, and the amount consumed.
Out of the 448 studies retrieved, fourteen cohorts from four studies (298 participants with Type-2 diabetes) were included. Dates fruit reduced cholesterol, odd ratio, -0.87, 95% , -1.39--0.35, P-value, 0.001, and for heterogeneity=90%. No significant changes were observed on low-density lipoprotein (odd ratio, -0.31, 95% , -0.65-0.03, and P-value, 0.08), triglycerides (odd ratio, -0.77, 95% , -2.17--0.63, P-value 0.28), and high-density lipoproteins (odd ratio, 0.03, 95% , -0.13-0.19, P-value, 0.69). The for heterogeneity were=99%, 95%, and 65% respectively.
Dates fruit could reduce total cholesterol, with a non-significant reduction in low-density lipoproteins. No significant effect was evident regarding triglycerides and high-density lipoproteins. Further larger studies with a high selection of controls and dates are needed.
血脂异常是心血管疾病及其他合并症的主要危险因素。将重点放在通过食物和营养来预防和治疗包括血脂异常在内的心血管危险因素是一种范式转变。这是第一项评估枣类水果与2型糖尿病患者血脂异常之间关联的荟萃分析。该研究旨在评估2型糖尿病患者中的这种关联。
检索了六个数据库，查找从数据库建立至2024年3月的相关文章。我们纳入了随机试验、采用其他方法的研究，排除了在健康人群中开展的研究。使用一份结构化清单，内容包括作者姓名、国家、发表年份、研究类型、研究持续时间、食用枣类水果前后的血脂谱、参与者的年龄和性别、枣的类型以及食用量。
在检索到的448项研究中，纳入了来自四项研究的14个队列（298名2型糖尿病患者）。枣类水果降低了胆固醇，比值比为-0.87，95%置信区间为-1.39至-0.35，P值为0.001，异质性I²为90%。低密度脂蛋白未观察到显著变化（比值比为-0.31，95%置信区间为-0.65至0.03，P值为0.08），甘油三酯（比值比为-0.77，95%置信区间为-2.17至-0.63，P值为0.28），以及高密度脂蛋白（比值比为0.03，95%置信区间为-0.13至0.19，P值为0.69）。这些指标的异质性I²分别为99%、95%和65%。
枣类水果可降低总胆固醇，低密度脂蛋白有不显著的降低。甘油三酯和高密度脂蛋白方面未观察到显著效果。需要开展进一步的、对照和枣类选择更严格的大型研究。
