Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
School of Stomatology, Qingdao University, Qingdao, China.
Front Immunol. 2023 Jun 2;14:1203071. doi: 10.3389/fimmu.2023.1203071. eCollection 2023.
Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and disorders have drawn extensive attention. In this review, we will focus on the relationship between cathepsins and oral diseases. We highlight the structural and functional properties of cathepsins related to oral diseases, as well as the regulatory mechanisms in tissue and cells and their therapeutic uses. Elucidating the associated mechanism between cathepsins and oral diseases is thought to be a promising strategy for the treatment of oral diseases and may be a starting point for further studies at the molecular level.
组织蛋白酶是溶酶体球蛋白水解酶的一种，对许多生理过程至关重要，包括骨基质的吸收、先天免疫、细胞凋亡、增殖、转移、自噬和血管生成。关于它们在人体生理过程和疾病中的作用的发现引起了广泛关注。在这篇综述中，我们将重点关注组织蛋白酶与口腔疾病的关系。我们强调了与口腔疾病相关的组织蛋白酶的结构和功能特性，以及组织和细胞中的调节机制及其治疗用途。阐明组织蛋白酶与口腔疾病之间的相关机制被认为是治疗口腔疾病的一种有前途的策略，并且可能是分子水平进一步研究的起点。
