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白藜芦醇对口腔和牙齿健康维护的潜在作用:一项综述

Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review.

作者信息

Farhad Shirin Zahra, Karbalaeihasanesfahani Amirreza, Dadgar Esmaeel, Nasiri Kamyar, Hosseini Narges Mohammad, Valian Neda, Esfahaniani Mahla, Nabi Afjadi Mohsen

机构信息

Department of Periodontics, Faculty of Dentistry, Isfahan(Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

Faculty of Dentistry, Semmelweis University, Budapest, Hungary.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb;398(2):1367-1389. doi: 10.1007/s00210-024-03457-1. Epub 2024 Sep 21.

Abstract

Resveratrol (RV-3, 5, 4'-trihydroxystilbene) is a natural compound found in plants like red grapes, berries, and peanuts, with promising effects on dental health. It helps strengthen tooth enamel by promoting remineralization, making the teeth more resistant to decay caused by acid-producing bacteria. RV also shields dentin, a vulnerable layer beneath the enamel, from erosion and sensitivity. Its anti-inflammatory properties can reduce inflammation associated with dental conditions such as pulpitis and endodontic diseases. Moreover, RV's antimicrobial activity inhibits the growth of bacteria involved in dental plaque and biofilm formation, preventing their accumulation on the tooth surface. This contributes to a healthier oral environment and prolongs the lifespan of dental restorative materials. However, the research on RV's impact on dental health is in its early stages, and further studies are needed to confirm potential benefits. Important factors such as determining the optimal dosage, understanding its bioavailability, and assessing potential side effects require further investigation. This review focuses on the important role of RV in promoting dental health. It delves into various aspects, including its impact on root health, maintenance of the dental pulp, care for tooth enamel, effectiveness of dental restorative materials, and health of dentin.

摘要

白藜芦醇(RV - 3,5,4'-三羟基茋)是一种在红葡萄、浆果和花生等植物中发现的天然化合物,对牙齿健康有显著作用。它通过促进再矿化来增强牙釉质,使牙齿更能抵抗产酸细菌引起的龋齿。白藜芦醇还能保护牙釉质下方脆弱的牙本质层免受侵蚀和敏感问题的影响。其抗炎特性可减轻与牙髓炎和牙髓病等牙齿疾病相关的炎症。此外,白藜芦醇的抗菌活性可抑制参与牙菌斑和生物膜形成的细菌生长,防止它们在牙齿表面积聚。这有助于营造更健康的口腔环境,并延长牙齿修复材料的使用寿命。然而,关于白藜芦醇对牙齿健康影响的研究尚处于早期阶段,需要进一步研究来证实其潜在益处。确定最佳剂量、了解其生物利用度以及评估潜在副作用等重要因素都需要进一步调查。这篇综述聚焦于白藜芦醇在促进牙齿健康方面的重要作用。它深入探讨了各个方面,包括对牙根健康的影响、牙髓的维护、牙釉质护理、牙齿修复材料的有效性以及牙本质健康。

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