Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Republic of Korea.
Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea.
Glob Heart. 2023 Jun 12;18(1):29. doi: 10.5334/gh.1209. eCollection 2023.
Limited evidence exists on the association between dietary fat intake and lipid profiles in Southeast Asian populations.
We aimed to examine the cross-sectional associations of dietary intake of total and specific types of fat with dyslipidemia in Filipino immigrant women in Korea.
We included 406 Filipino women married to Korean in the Filipino Women's Diet and Health Study (FiLWHEL). Dietary fat intake was assessed using 24-hour recalls. Impaired blood lipid profiles were defined as high total cholesterol (TC) (≥200 mg/dL), high triglyceride (TG) (≥150 mg/dL), high LDL Cholesterol (LDL-C) (≥ 130 mg/dL), or low HDL cholesterol (HDL-C) (<50 mg/dL). The genomic DNA samples were genotyped using DNA chip. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression.
Substituting carbohydrates with dietary saturated fat (SFA) intake was associated with increased prevalence of dyslipidemia; ORs (95% CIs) for subsequent tertiles compared to the first tertile were 2.28 (1.19-4.35), and 2.88 (1.29-6.39) ( = 0.02). When we examined individual markers, ORs (95% CIs, ) comparing the third to the first tertile were 3.62 (1.53-8.55, 0.01) for high TC, 1.46 (0.42-5.10, 0.72) for high TG, 4.00 (1.48-10.79, 0.02) for high LDL-C, and 0.69 (0.30-1.59, 0.36) for low HDL-C. When we examined the interaction by LDL-C-related polymorphisms, the association with dyslipidemia was more pronounced among participants with CC alleles than among those with T alleles of rs6102059 ( = 0.01).
High dietary SFA intake was significantly associated with a high prevalence of dyslipidemia in Filipino women in Korea. Further prospective cohort studies are warranted to determine risk factors for CVD in Southeast Asian populations.
关于东南亚人群饮食脂肪摄入与血脂谱之间的关系，目前的证据有限。
本研究旨在检验菲律宾移民女性的膳食总脂肪和特定类型脂肪摄入与血脂异常的横断面关联。
我们纳入了在菲律宾妇女饮食与健康研究（FiLWHEL）中与韩国男性结婚的 406 名菲律宾女性。使用 24 小时回顾法评估膳食脂肪摄入量。血脂异常定义为总胆固醇（TC）升高（≥200mg/dL）、甘油三酯（TG）升高（≥150mg/dL）、低密度脂蛋白胆固醇（LDL-C）升高（≥130mg/dL）或高密度脂蛋白胆固醇（HDL-C）降低（<50mg/dL）。使用 DNA 芯片对基因组 DNA 样本进行基因分型。使用多变量逻辑回归计算比值比（OR）和 95%置信区间（CI）。
用膳食饱和脂肪（SFA）替代碳水化合物的摄入与血脂异常的患病率增加有关；与第一三分位相比，随后三分位的 OR（95%CI）分别为 2.28（1.19-4.35）和 2.88（1.29-6.39）（=0.02）。当我们检查个体标志物时，与第一三分位相比，第三三分位的 OR（95%CI）分别为高 TC（3.62[1.53-8.55]，0.01）、高 TG（1.46[0.42-5.10]，0.72）、高 LDL-C（4.00[1.48-10.79]，0.02）和低 HDL-C（0.69[0.30-1.59]，0.36）。当我们按 LDL-C 相关多态性检查交互作用时，与 rs6102059 中 CC 等位基因相比，TC 等位基因的参与者中这种关联更为明显（=0.01）。
高膳食 SFA 摄入与韩国菲律宾女性血脂异常的高患病率显著相关。需要进一步的前瞻性队列研究来确定东南亚人群心血管疾病的危险因素。
