Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Chem Soc Rev. 2023 Jul 3;52(13):4392-4442. doi: 10.1039/d3cs00227f.
Metal agents have made incredible strides in preclinical research and clinical applications in recent years, but their short emission/absorption wavelengths continue to be a barrier to their distribution, therapeutic action, visual tracking, and efficacy evaluation. Nowadays, the near-infrared window (NIR, 650-1700 nm) provides a more accurate imaging and treatment option. Thus, there has been ongoing research focusing on developing multifunctional NIR metal agents for imaging and therapy that have deeper tissue penetration. The design, characteristics, bioimaging, and therapy of NIR metal agents are covered in this overview of papers and reports published to date. To start with, we focus on describing the structure, design strategies, and photophysical properties of metal agents from the NIR-I (650-1000 nm) to NIR-II (1000-1700 nm) region, in order of molecular metal complexes (MMCs), metal-organic complexes (MOCs), and metal-organic frameworks (MOFs). Next, the biomedical applications brought by these superior photophysical and chemical properties for more accurate imaging and therapy are discussed. Finally, we explore the challenges and prospects of each type of NIR metal agent for future biomedical research and clinical translation.
近年来，金属试剂在临床前研究和临床应用方面取得了令人瞩目的进展，但它们的短发射/吸收波长仍然是其分布、治疗作用、可视化跟踪和疗效评估的障碍。如今，近红外窗口（NIR，650-1700nm）提供了更准确的成像和治疗选择。因此，目前一直在研究开发用于成像和治疗的多功能近红外金属试剂，以实现更深的组织穿透。本文综述了迄今为止发表的论文和报告，介绍了近红外金属试剂的设计、特性、生物成像和治疗。首先，我们专注于描述从近红外-I（650-1000nm）到近红外-II（1000-1700nm）区域的分子金属配合物（MMCs）、金属有机配合物（MOCs）和金属有机骨架（MOFs）的结构、设计策略和光物理性质。接下来，讨论了这些优越的光物理和化学性质为更准确的成像和治疗带来的生物医学应用。最后，我们探讨了每种类型的近红外金属试剂在未来生物医学研究和临床转化中的挑战和前景。
