四癌菌素，新型抗肿瘤抗生素。II. 分离、表征及抗肿瘤活性。
Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.
作者信息
Tamaoki T, Kasai M, Shirahata K, Ohkubo S, Morimoto M, Mineura K, Ishii S, Tomita F
出版信息
J Antibiot (Tokyo). 1980 Sep;33(9):946-50. doi: 10.7164/antibiotics.33.946.
Novel antitumor antibiotics, tetrocarcin complex composed of three components (A, B and C) were isolated from the culture broth of Micromonospora chalcea KY11091 through various procedures. Tetrocarcins showed marked activity against experimental tumors such as mouse sarcoma 180 and mouse leukemia P388. Multiple injections showed better therapeutic effect against tumors. Mode of action of tetrocarcin A against Bacillus subtilis was found to be through the inhibition of RNA synthesis.
通过各种程序从铜色小单孢菌KY11091的培养液中分离出了新型抗肿瘤抗生素——由三种成分（A、B和C）组成的四霉素复合物。四霉素对小鼠肉瘤180和小鼠白血病P388等实验性肿瘤显示出显著活性。多次注射对肿瘤显示出更好的治疗效果。发现四霉素A对枯草芽孢杆菌的作用方式是通过抑制RNA合成。
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