Gao Zhenzhou, Qin Haokai, Li Bao, Zhao Hongjun, Zhang Mingqing
School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Department of Urinary Surgery, Weifang People's Hospital, Weifang, Shandong, China.
Front Oncol. 2025 Jul 29;15:1619030. doi: 10.3389/fonc.2025.1619030. eCollection 2025.
Adrenal Ganglioneuroma (AGN) is a rare benign tumor that is mostly nonfunctioning and usually presents without significant clinical symptoms. AGN can undergo calcification, but rarely presents with hemorrhage, necrosis, or cystic changes. This article reports two cases of adrenal ganglioneuroma. One patient had normal clinical and biochemical parameters but presented with hypertension; the other patient had elevated cortisol levels and the tumor exhibited liquefactive necrosis, which is extremely rare in AGN. To the best of our knowledge, this is the first report of adrenal ganglioneuroma with simultaneous localized hemangiomatous proliferation and liquefactive necrosis within the tumor. AGN cannot be definitively diagnosed by imaging alone; a pathological examination is required for a final diagnosis. Both patients in this report underwent laparoscopic tumor resection, and their postoperative recovery was satisfactory.
肾上腺神经节细胞瘤（AGN）是一种罕见的良性肿瘤，大多无功能，通常无明显临床症状。AGN可发生钙化，但很少出现出血、坏死或囊性改变。本文报告两例肾上腺神经节细胞瘤。一例患者临床和生化指标正常，但出现高血压；另一例患者皮质醇水平升高，肿瘤表现为液化性坏死，这在AGN中极为罕见。据我们所知，这是首例关于肾上腺神经节细胞瘤同时伴有肿瘤内局限性血管瘤样增生和液化性坏死的报告。AGN不能仅通过影像学明确诊断；最终诊断需要病理检查。本报告中的两名患者均接受了腹腔镜肿瘤切除术，术后恢复良好。
