Department of Physical Therapy, Faculty of Health Science, Juntendo University, 3-2-12 Hongo Bunkyo-Ku, Tokyo, 113-0033, Japan.
Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, 7-430, Morioka, Obu, Aichi, 474-8511, Japan.
Aging Clin Exp Res. 2023 Sep;35(9):1937-1944. doi: 10.1007/s40520-023-02474-z. Epub 2023 Jun 19.
Although overlapping frailty and fear of falling (FoF) are likely to increase with population aging, the combined effect of frailty and FoF on incident disability is not yet well understood.
The purpose of this study is to examine whether frailty combined with FoF increased the risk of incident disability in older adults. Our secondary purpose was to clarify the synergistic effect of frailty and FoF on incident disability.
This is a prospective study. Participants were 9372 older adults (mean age 73.5 years). Frailty status was assessed using the Japanese Cardiovascular Health Study index, and FoF was measured using two closed questions. Incident disability was prospectively monitored by their long-term care insurance records.
During the follow-up period (mean duration 23.4 months), 487 (5.2%) participants developed disability. The proportion of incident disability linearly increased according to FoF level regardless of baseline frailty status. Frail participants with FoF had a higher risk of incident disability than those with frailty only or neither (adjusted hazard ratio [HR] 2.63, 95% confidence interval [CI] 1.95-3.54). Frailty in combination with excessive FoF further increased the risk of incident disability (adjusted HR 4.30, 95% CI 2.56-7.23) although no synergistic effect was observed (relative excessive risk due to interaction 1.69, 95% CI - 0.55, 3.93).
The overlapping status of frailty and FoF, especially excessive FoF, increases the risk of incident disability in older adults.
尽管衰弱和恐摔(Fear of Falling,FoF)可能会随着人口老龄化而重叠增加,但衰弱和 FoF 对残疾发生的综合影响尚不清楚。
本研究旨在探讨衰弱合并 FoF 是否会增加老年人残疾发生的风险。我们的次要目的是阐明衰弱和 FoF 对残疾发生的协同作用。
这是一项前瞻性研究。参与者为 9372 名老年人(平均年龄 73.5 岁)。使用日本心血管健康研究指数评估衰弱状况,使用两个封闭问题评估 FoF。通过长期护理保险记录前瞻性监测残疾发生情况。
在随访期间(平均持续时间 23.4 个月),487 名(5.2%)参与者发生了残疾。无论基线衰弱状况如何,根据 FoF 水平,残疾发生的比例呈线性增加。有 FoF 的衰弱参与者比仅有衰弱或两者都没有的参与者发生残疾的风险更高(调整后的危险比 [Hazard Ratio,HR] 2.63,95%置信区间 [Confidence Interval,CI] 1.95-3.54)。衰弱合并过度 FoF 进一步增加了残疾发生的风险(调整后的 HR 4.30,95% CI 2.56-7.23),尽管没有观察到协同作用(交互作用的相对过度风险 1.69,95% CI-0.55,3.93)。
衰弱和 FoF 的重叠状态,特别是过度的 FoF,会增加老年人残疾发生的风险。