Department of Otorhinolaryngology - Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, Helsinki, Finland.
Acta Oncol. 2023 Jun;62(6):541-549. doi: 10.1080/0284186X.2023.2224053. Epub 2023 Jun 19.
While certain occupations, such as agriculture and fishery, have been associated with an increased risk of lip cancer, the occupational risk profile of lip cancer and its change over time remain poorly known. This study aims to evaluate the incidence of lip cancer across different occupations in the Nordic countries.
The Nordic Occupational Cancer Study (NOCCA) covers 14.9 million people and includes 45 years of cancer incidence data, from 1961 to 2005, linked to occupational categories for all the five Nordic populations. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were used to quantify the risk of lip cancer across occupational categories relative to the entire national populations.
There were a total of 14,477 male and 3008 female lip cancer patients identified during follow up. The highest SIRs were observed among male fishermen (SIR 2.26, 95% CI: 2.04-2.50), gardeners (SIR 1.60, 95% CI: 1.48-1.72), and farmers (SIR 1.60, 95% CI: 1.55-1.66). A significantly reduced risk of lip cancer (SIR < 0.50) was observed among male physicians, teachers, religious workers, artistic workers, journalists, administrators, printers, waiters, and hairdressers. Among women, no occupations were associated with an increased risk of lip cancer.
The incidence of lip cancer varies widely between outdoor and indoor occupations. Occupations involving outdoor activity and exposure to sunlight show the most elevated SIRs.
尽管某些职业，如农业和渔业，与唇癌风险增加有关，但唇癌的职业风险概况及其随时间的变化仍知之甚少。本研究旨在评估北欧国家不同职业的唇癌发病率。
北欧职业癌症研究（NOCCA）涵盖 1490 万人，包含 1961 年至 2005 年 45 年的癌症发病率数据，并与所有五个北欧人群的职业类别相关联。使用标准化发病率比（SIR）及其 95%置信区间（CI）来量化相对于整个国家人群，职业类别中唇癌的风险。
在随访期间共发现 14477 名男性和 3008 名女性唇癌患者。男性渔民（SIR 2.26，95%CI：2.04-2.50）、园丁（SIR 1.60，95%CI：1.48-1.72）和农民（SIR 1.60，95%CI：1.55-1.66）的 SIR 最高。男性医生、教师、宗教工作者、艺术工作者、记者、行政人员、印刷工、服务员和理发师的唇癌风险显著降低（SIR<0.50）。在女性中，没有职业与唇癌风险增加相关。
唇癌的发病率在户外和室内职业之间差异很大。涉及户外活动和暴露于阳光的职业显示出最高的 SIR。
