From the Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University.
Plast Reconstr Surg. 2024 Sep 1;154(3):444e-450e. doi: 10.1097/PRS.0000000000010841. Epub 2023 Jun 20.
Androgenic alopecia (AGA) is characterized by progressive hair follicle miniaturization. Novel treatments are needed to intervene in the miniaturization process. The authors aimed to evaluate the efficacy, safety, effectiveness, and effective population of autologous hair follicle mesenchymal stem cell therapy for the treatment of advanced AGA in Chinese individuals.
Fifty patients ranging in age from 25 to 45 years (average, 32 ± 1.24 years) were included. None of them had ever used minoxidil, finasteride, or other drugs to promote hair growth. Healthy hair follicles were extracted from the occipital area and treated to obtain hair follicle mesenchymal stem cell suspensions. The recipient sites were divided into 2 groups. Nine points were injected in a 1-cm 2 area, and 100 µL of solution containing either 1 × 10 5 cells or normal saline was injected at each point. The follow-up duration was 9 months. Observers were blinded to patient groupings and measurements.
An increased proportion of terminal hair and hair shaft diameter was observed in the experimental group at 1 month. The effect lasted for 3 months. The hair-thickening effect of advanced miniaturized hair follicles with hair shaft diameter less than 60 µm was more notable than that for above 60 µm. No patient experienced any obvious side effects.
Hair follicle mesenchymal stem cells were effective in the treatment of advanced AGA in Chinese individuals. A hair shaft diameter of 60 µm can be used as a key index to predict the effectiveness of the therapy.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
雄激素性脱发（AGA）的特征是毛囊进行性微小化。需要新的治疗方法来干预微小化过程。作者旨在评估自体毛囊间充质干细胞治疗中国人晚期 AGA 的疗效、安全性、有效性和有效人群。
纳入 50 名年龄在 25 至 45 岁之间（平均 32 ± 1.24 岁）的患者。他们均未曾使用过米诺地尔、非那雄胺或其他促进毛发生长的药物。从枕部提取健康的毛囊并进行处理，以获得毛囊间充质干细胞悬液。受区分为两组。在 1cm 2 区域的 9 个点进行注射，每个点注射 100µL 含有 1×10 5 个细胞或生理盐水的溶液。随访时间为 9 个月。观察者对患者分组和测量结果进行了盲法评估。
实验组在 1 个月时观察到终末毛和毛干直径的比例增加。效果持续 3 个月。毛干直径小于 60µm 的晚期微小化毛囊的增粗效果比毛干直径大于 60µm 的更为显著。没有患者出现明显的不良反应。
毛囊间充质干细胞对中国人晚期 AGA 治疗有效。毛干直径 60µm 可作为预测治疗效果的关键指标。
临床问题/证据水平：治疗，II 级。
