Clinic for Obstetrics and Gynecology, Veterinary Medicine, Van YYÜ, Van, Turkey.
Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals with Ambulatory Service, Faculty of Veterinary Medicine, Justus-Liebig-University, Giessen, Germany.
Vet Med Sci. 2023 Jul;9(4):1764-1770. doi: 10.1002/vms3.1145. Epub 2023 Jun 19.
The current study investigates how uterine torsion influences placental oestrogens and progesterone blood concentrations in intrapartum cows. Our research tests the hypothesis that intrapartum uterine torsion impairs the ability of the placenta to synthesize steroids and may also suppress the release of synthesized steroids into the maternal circulation.
The study included a total number of 37 intrapartum dairy cows of various breeds and ages. These animals were transported to our clinic by their owners. Furthermore, general and obstetrical examinations of all these animals were performed in our clinic. The uterine torsion (UT) group consisted of 20 animals. The presence of UT was verified during clinical general examinations by vaginal and transrectal examination. The comparison (C) group included 17 animals whose birth was undisturbed or could be terminated with moderate obstetrical assistance. The clinical examination of group C animals showed no problems with their general health and genital organs. Blood samples were collected immediately after the initial obstetrical examination from 37 cows for radioimmunological measurement of estradiol-17β (E2), free total estrogen (FTE), conjugated total estrogen (CTE), and progesterone (P4).
In terms of P4, there was no statistical difference between the two groups. For all estrogen parameters, however, concentrations were significantly lower in the UT group than in the C group. In the correlation analysis, there was a significant correlation between the P4 and the FTE in the C group. Furthermore, the positive correlation between all estrogen parameters in the UT group was significant. In group C, significant positive correlations were found apart from the correlation between E2 and CTE.
The results are consistent with the hypothesis and suggest that in UT animals processes dependent on estrogens or other placental hormones may be impaired during the peri- or postpartum period.
本研究旨在探讨分娩过程中子宫扭转如何影响胎盘雌激素和孕激素的血液浓度。我们的研究检验了这样一个假设，即在分娩过程中子宫扭转会损害胎盘合成类固醇的能力，并且可能会抑制合成的类固醇向母体循环中的释放。
本研究共纳入了 37 头不同品种和年龄的分娩奶牛。这些动物由其主人运送到我们的诊所。此外，我们还对所有这些动物进行了一般和产科检查。子宫扭转（UT）组包括 20 头动物。通过阴道和直肠检查在临床一般检查中证实了 UT 的存在。对照组（C 组）包括 17 头动物，其分娩过程未受干扰或可在适度的产科协助下终止。C 组动物的临床检查显示其一般健康和生殖器官没有问题。从 37 头奶牛中采集了初始产科检查后立即采集的血液样本，用于放射免疫测定雌二醇-17β（E2）、游离总雌激素（FTE）、结合总雌激素（CTE）和孕酮（P4）。
在 P4 方面，两组之间没有统计学差异。然而，对于所有雌激素参数，UT 组的浓度明显低于 C 组。在相关分析中，C 组中 P4 与 FTE 之间存在显著相关性。此外，UT 组中所有雌激素参数之间的正相关也是显著的。在 C 组中，除了 E2 和 CTE 之间的相关性外，还发现了显著的正相关性。
这些结果与假设一致，表明在 UT 动物中，依赖于雌激素或其他胎盘激素的过程可能在围产期或产后期间受损。
