Feng Shuyan, Zhang Chi, Chen Shanshan, He Ruonan, Chao Guanqun, Zhang Shuo
Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, People's Republic of China.
J Inflamm Res. 2023 Jun 14;16:2491-2501. doi: 10.2147/JIR.S407521. eCollection 2023.
Toll-like receptor 5 (TLR5) is a pattern recognition receptor that specifically recognizes flagellin and consequently plays a crucial role in the control of intestinal homeostasis by activating innate and adaptive immune responses. TLR5 overexpression, on the other hand, might disrupt the intestinal mucosal barrier, which serves as the first line of defense against harmful microbes. The intestine symbiotic bacteria, mucous layer, intestinal epithelial cells (IECs), adherens junctions (such as tight junctions and peripheral membrane proteins), the intestinal mucosal immune system, and cytokines make up the intestinal mucosal barrier. Impaired barrier function has been linked to intestinal illnesses such as inflammatory bowel disease (IBD). IBD is a persistent non-specific inflammatory illness of the digestive system with an unknown cause. It is now thought to be linked to infection, environment, genes, immune system, and the gut microbiota. The significance of immunological dysfunction in IBD has received more attention in recent years. The purpose of this paper is to explore TLR5's position in the intestinal mucosal barrier and its relevance to IBD.
Toll样受体5（TLR5）是一种模式识别受体，可特异性识别鞭毛蛋白，进而通过激活先天性和适应性免疫反应在维持肠道内环境稳定中发挥关键作用。另一方面，TLR5的过度表达可能会破坏肠道黏膜屏障，而肠道黏膜屏障是抵御有害微生物的第一道防线。肠道共生细菌、黏液层、肠道上皮细胞（IECs）、黏附连接（如紧密连接和外周膜蛋白）、肠道黏膜免疫系统和细胞因子共同构成了肠道黏膜屏障。屏障功能受损与炎症性肠病（IBD）等肠道疾病有关。IBD是一种病因不明的持续性非特异性消化系统炎症性疾病。目前认为它与感染、环境、基因、免疫系统和肠道微生物群有关。近年来，免疫功能障碍在IBD中的重要性受到了更多关注。本文旨在探讨TLR5在肠道黏膜屏障中的地位及其与IBD的相关性。
