Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095, P. R. China.
Org Lett. 2023 Jun 30;25(25):4720-4724. doi: 10.1021/acs.orglett.3c01680. Epub 2023 Jun 20.
Herein, a novel and expedient method was established for the synthesis of polyarylfuran derivatives. The coupling of allenylphosphine oxide and bromophenol or bromonaphthol enabled by visible light and palladium catalysis directly furnishes polyarylfuran skeletons, which involves a radical tandem cyclization and cascade C(sp)-P(V) bond cleavage. This protocol features easy operation, a broad substrate scope, and a high step economy, affording polyarylfurans in moderate to good yields.
本文建立了一种新颖、简便的聚芳呋喃衍生物合成方法。通过可见光和钯催化，烯丙基膦氧化物与溴苯酚或溴萘酚直接偶联，直接生成聚芳呋喃骨架，涉及自由基串联环化和级联 C(sp)-P(V)键断裂。该方法操作简单，底物适用范围广，具有较高的步骤经济性，可中等至良好收率地得到聚芳呋喃。
