National Key Laboratory of Wheat and Maize Crop Science/CIMMYT-China Wheat and Maize Joint Research Center/Agronomy College, Henan Agricultural University, Zhengzhou, China.
Proteomics. 2023 Oct;23(19):e2300045. doi: 10.1002/pmic.202300045. Epub 2023 Jun 20.
Lysine 2-hydroxyisobutyrylation (Khib) is a novel protein post-translational modifications (PTMs) observed in both eukaryotes and prokaryotes. Recent studies suggested that this novel PTM has the potential to regulate different proteins in various pathways. Khib is regulated by lysine acyltransferases and deacylases. This novel PTM reveals interesting connections between modifications and protein physiological functions, including gene transcription, glycolysis and cell growth, enzymic activity, sperm motility, and aging. Here, we review the discovery and the current understanding of this PTM. Then, we outline the networks of complexity of interactions among PTMs in plants, and raise possible directions of this novel PTM for future investigations in plants.
赖氨酸 2-羟基异丁酰化（Khib）是一种在真核生物和原核生物中都存在的新型蛋白质翻译后修饰（PTM）。最近的研究表明，这种新型 PTM 有可能调节不同途径中的不同蛋白质。Khib 受赖氨酸酰基转移酶和脱酰酶的调节。这种新型 PTM 揭示了修饰与蛋白质生理功能之间的有趣联系，包括基因转录、糖酵解和细胞生长、酶活性、精子活力和衰老。在这里，我们回顾了这一 PTM 的发现和目前的认识。然后，我们概述了植物中 PTM 相互作用网络的复杂性，并为该新型 PTM 在植物中的未来研究提出了可能的方向。
