Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284, United States.
Org Lett. 2023 Jun 30;25(25):4644-4649. doi: 10.1021/acs.orglett.3c01459. Epub 2023 Jun 20.
Herein, we report the development of a Cu-catalyzed enantioselective borylative aminoallylation of aldehydes using a N-substituted allene to access boryl-substituted 1,2-aminoalcohol synthons for diversification to chiral heteroatom-rich organic compounds. The reported reaction provides access to several different substitution patterns of chiral 1,2-aminoalcohol products from the same readily available starting materials with high diastereo- and enantioselectivity.
在此，我们报告了一种使用 N-取代烯丙基的铜催化对映选择性硼化氨基丙酰化醛的方法，用于构建硼取代的 1,2-氨基醇合成子，以多样化到手性杂原子丰富的有机化合物。所报道的反应可从相同易得的起始原料中获得几种不同取代模式的手性 1,2-氨基醇产物，具有高的非对映选择性和对映选择性。
