School of Chemical Engineering and Technology, Hebei University of Technology, Xiping Road, Tianjin 300401, P. R. China.
School of Pharmacy, Shandong New Drug Loading & Release Technology and Preparation Engineering Laboratory, Binzhou Medical University, 346 Guanhai Road, Yantai 264003, P. R. China.
J Mater Chem B. 2023 Jul 12;11(27):6404-6411. doi: 10.1039/d3tb00342f.
Designing a multifunctional nanoplatform that combines multiple treatments has emerged as an innovative cancer treatment strategy. A simple and clear route is put forward to develop Cu-doped zinc phosphate coated prussian blue nanoparticles (designated as PB@Cu/ZnP NPs) integrating tri-modal therapy (chemo, chemodynamic and photothermal therapy) for maximizing anti-tumor efficacy. The obtained PB@Cu/ZnP NPs possess drug loading capacity due to the mesoporous structure present in the Cu-doped ZnP shell. In addition, the Cu-doped ZnP shell can gradually degrade in response to the mildly acidic tumor microenvironment to release DOX and Cu, where the released drug plays the role of chemotherapy agent and the Cu can react with intracellular glutathione to achieve a Cu-mediated Fenton-like reaction for chemodynamic therapy. Moreover, under laser irradiation, the heat garnered by the photothermal conversion of PB can be applied for photothermal therapy and enhance the generation of toxic ˙OH as well as the amount of DOX released, further boosting chemo- and chemodynamic therapy to realize a combined therapy. Importantly, the PB@Cu/ZnP NPs effectively limit the growth of tumors the coordinated action of chemo/chemodynamic/photothermal therapy and no noticeable systematic toxicity can be found in mice. Taken together, the PB@Cu/ZnP NPs can act as a prospective therapeutic nanoplatform for multi-modal therapy of tumors.
设计一种将多种治疗方法结合在一起的多功能纳米平台已成为一种创新的癌症治疗策略。本文提出了一种简单明了的方法来开发普鲁士蓝纳米粒子（PB）负载铜掺杂磷酸锌（Cu/ZnP）纳米粒子（设计为 PB@Cu/ZnP NPs），将三模态治疗（化疗、化学动力学和光热治疗）整合在一起，以最大限度地提高抗肿瘤疗效。由于 Cu 掺杂的 ZnP 壳中存在介孔结构，所得到的 PB@Cu/ZnP NPs 具有载药能力。此外，Cu 掺杂的 ZnP 壳可以逐渐降解，以响应轻度酸性的肿瘤微环境，释放 DOX 和 Cu，其中释放的药物发挥化疗剂的作用，而 Cu 可以与细胞内的谷胱甘肽反应，实现 Cu 介导的芬顿样反应，用于化学动力学治疗。此外，在激光照射下，PB 的光热转换产生的热量可用于光热治疗，并增强有毒˙OH 的产生和 DOX 的释放量，进一步增强化疗和化学动力学治疗，实现联合治疗。重要的是，PB@Cu/ZnP NPs 通过化疗/化学动力学/光热治疗的协同作用有效地限制了肿瘤的生长，并且在小鼠中没有发现明显的系统毒性。综上所述，PB@Cu/ZnP NPs 可以作为一种用于肿瘤多模态治疗的有前途的治疗性纳米平台。
