Kayser K, Ebert W, Merkle N M, Becker H D
J Cancer Res Clin Oncol. 1986;111(3):277-83. doi: 10.1007/BF00389245.
A total of 126 resection specimens from malignant lung tumors were cut into serial sections, and tumor volume and macroscopic growth pattern were computed. Four characteristic tumor growth patterns could be separated: Tumors growing in bizarre, irregular shapes; Tumors growing in spheroid shapes; Tumors growing in ellipsoid shapes; Tumors growing in mixed growth pattern. The immunologic response of the host tissue was analyzed grading the number of lymphocytes, plasma cells, macrophages in and at the boundary of the tumor tissue. Lymphocytic subpopulations were analyzed in 46 cases using monoclonal antibodies (BS3/BS4; T3, OKT4, OKT8, OKT11, OKT14). The majority of lymphocytes were T-lymphocytes and monocytes in cases with inflammatory response of host tissue. The ratio of inducer/helper subset (OKT4+) compared to suppressor/cytotoxic subset (OKT8+) was similar in expression as reported for circulating peripheral T-lymphocytes. The different growth patterns depend upon cell type of tumor, immunologic response of the host tissue, and tumor volume. The findings indicate that tumor progression into lung tissue is partly due to "localized metastatic growth" of different tumor cell subpopulations.
共将126份恶性肺肿瘤切除标本制成连续切片，并计算肿瘤体积和宏观生长模式。可区分出四种特征性肿瘤生长模式：呈奇异不规则形状生长的肿瘤；呈球形生长的肿瘤；呈椭圆形生长的肿瘤；呈混合生长模式的肿瘤。分析宿主组织的免疫反应，对肿瘤组织内部及边界处的淋巴细胞、浆细胞、巨噬细胞数量进行分级。使用单克隆抗体（BS3/BS4；T3、OKT4、OKT8、OKT11、OKT14）对46例病例的淋巴细胞亚群进行分析。在宿主组织有炎症反应的病例中，大多数淋巴细胞为T淋巴细胞和单核细胞。诱导/辅助亚群（OKT4 +）与抑制/细胞毒性亚群（OKT8 +）的比例在表达上与循环外周T淋巴细胞的报道相似。不同的生长模式取决于肿瘤的细胞类型、宿主组织的免疫反应和肿瘤体积。研究结果表明，肿瘤向肺组织的进展部分归因于不同肿瘤细胞亚群的“局部转移性生长”。
