与中国南方汉族人群缺血性中风易感性相关的基因变异。
Genetic Variants of Associated with Ischemic Stroke Susceptibility in the Han Population from Southern China.
作者信息
Huang Kang, Ma Tianyi, Li Qiang, Zhou Yilei, Qin Ting, Zhong Zanrui, Tang Shilin, Zhang Wei, Zhong Jianghua, Lu Shijuan
机构信息
Department of Cardiovascular Medicine, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, People's Republic of China.
Medical College, Jingchu University of Technology, Jingmen, Hubei, People's Republic of China.
出版信息
Pharmgenomics Pers Med. 2023 Jun 15;16:599-607. doi: 10.2147/PGPM.S413632. eCollection 2023.
BACKGROUND
The pathophysiological mechanism of ischemic stroke is complex. Traditional risk factors cannot fully or only partially explain the occurrence and development of IS. Genetic factors are getting more and more attention. Our study aimed to explore the association between gene polymorphism and susceptibility to IS.
METHODS
A total of 1322 volunteers were enrolled to perform an association analysis through SNPStats online software. Using FPRP (false-positive report probability) to detect whether the result is a noteworthy finding. The interaction of SNP-SNP in IS risk was assessed by multi-factor dimensionality reduction. Statistical analysis of this study was mainly completed by SPSS 22.0 software.
RESULTS
Mutant allele "A" (OR = 1.24) and genotype "AA" (OR = 1.49) or "GA" (OR = 1.26) of rs2108622 are risk genetic factors for IS. Rs2108622 is significantly associated with an increased risk of IS among subjects who are females, aging >60 years old, with BMI ≥24 kg/m, and smoking or drinking volunteers. -rs3093106 and -rs3093105 are associated with susceptibility to IS among smoking, drinking subjects, or IS patients complicated with hypertension.
CONCLUSION
-rs2108622, -rs3093106, and -rs3093105 are associated with an increased risk of IS.
背景
缺血性中风的病理生理机制复杂。传统危险因素无法完全或仅部分解释缺血性中风的发生和发展。遗传因素越来越受到关注。我们的研究旨在探讨基因多态性与缺血性中风易感性之间的关联。
方法
共纳入1322名志愿者，通过SNPStats在线软件进行关联分析。使用假阳性报告概率（FPRP）检测结果是否为值得关注的发现。通过多因素降维评估缺血性中风风险中SNP-SNP的相互作用。本研究的统计分析主要由SPSS 22.0软件完成。
结果
rs2108622的突变等位基因“A”（OR = 1.24）和基因型“AA”（OR = 1.49）或“GA”（OR = 1.26）是缺血性中风的风险遗传因素。rs2108622与女性、年龄>60岁、BMI≥24 kg/m以及吸烟或饮酒志愿者中缺血性中风风险增加显著相关。-rs3093106和-rs3093105与吸烟、饮酒者或合并高血压的缺血性中风患者对缺血性中风的易感性相关。
结论
-rs2108622、-rs3093106和-rs3093105与缺血性中风风险增加相关。
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