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利用全息非相干定量相成像对药物的预期迁移抑制潜力进行初步评估。

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging.

作者信息

Šuráňová Markéta, Ďuriš Miroslav, Štenglová Netíková Irena, Brábek Jan, Horák Tomáš, Jůzová Veronika, Chmelík Radim, Veselý Pavel

机构信息

Institute of Physical Engineering (IPE), Faculty of Mechanical Engineering, Brno University of Technology, Brno, Czech Republic.

CEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.

出版信息

Biomed Opt Express. 2023 May 16;14(6):2689-2708. doi: 10.1364/BOE.488630. eCollection 2023 Jun 1.

DOI:10.1364/BOE.488630
PMID:37342686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10278600/
Abstract

Solid tumor metastases cause most cancer-related deaths. The prevention of their occurrence misses suitable anti-metastases medicines newly labeled as migrastatics. The first indication of migrastatics potential is based on an inhibition of enhanced migration of tumor cell lines. Therefore, we decided to develop a rapid test for qualifying the expected migrastatic potential of some drugs for repurposing. The chosen Q-PHASE holographic microscope provides reliable multifield time-lapse recording and simultaneous analysis of the cell morphology, migration, and growth. The results of the pilot assessment of the migrastatic potential exerted by the chosen medicines on selected cell lines are presented.

摘要

实体瘤转移导致了大多数与癌症相关的死亡。预防其发生缺少新标记为迁移抑制剂的合适抗转移药物。迁移抑制剂潜力的首个迹象基于对肿瘤细胞系增强迁移的抑制。因此，我们决定开发一种快速测试，以鉴定某些药物用于重新利用时预期的迁移抑制潜力。所选用的Q-PHASE全息显微镜可提供可靠的多视野延时记录，并能同时分析细胞形态、迁移和生长情况。本文展示了所选药物对所选细胞系施加的迁移抑制潜力的初步评估结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/847beeeb1f04/boe-14-6-2689-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/58b3c7d4028a/boe-14-6-2689-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/e18216b992ca/boe-14-6-2689-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/3c6bdca34b70/boe-14-6-2689-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/3fc953ebc607/boe-14-6-2689-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/1088ae4fd815/boe-14-6-2689-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/2aaf07872d60/boe-14-6-2689-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/847beeeb1f04/boe-14-6-2689-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/58b3c7d4028a/boe-14-6-2689-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/e18216b992ca/boe-14-6-2689-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/3c6bdca34b70/boe-14-6-2689-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/3fc953ebc607/boe-14-6-2689-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/1088ae4fd815/boe-14-6-2689-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/2aaf07872d60/boe-14-6-2689-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d42/10278600/847beeeb1f04/boe-14-6-2689-g007.jpg

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本文引用的文献

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Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction.通过定量相位和流动应力感应测量癌细胞粘弹性。
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具有ROCK-2抑制作用的贝拉莫德：从化学研发到获得美国食品药品监督管理局批准用于治疗慢性移植物抗宿主病的治疗性研发历程
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Molecular and cellular functions of long non-coding RNAs in prostate and breast cancer.长非编码 RNA 在前列腺癌和乳腺癌中的分子和细胞功能。
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Niclosamide Suppresses Migration and Invasion of Human Osteosarcoma Cells by Repressing TGFBI Expression via the ERK Signaling Pathway.尼克罗米胺通过抑制 ERK 信号通路抑制 TGFBI 表达抑制人骨肉瘤细胞的迁移和侵袭。
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