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探索基于聚乙烯醇/壳聚糖的纳米纤维基质用于红霉素递送的潜力：制备与评估。

Exploring the potential of a polyvinyl alcohol/chitosan-based nanofibrous matrix for erythromycin delivery: fabrication, and evaluation.

作者信息

Cheng Yuan, Farasati Far Bahareh, Jahanbakhshi Mehdi, Bahrami Shima, Tamimi Pegah, Sedaghat Meysam, Ghazizadeha Elham

机构信息

School of Materials and Chemical Engineering, Chuzhou University Chuzhou 239000 China.

Department of Chemistry, Iran University of Science and Technology Tehran Iran

出版信息

RSC Adv. 2023 Jun 19;13(27):18450-18460. doi: 10.1039/d3ra02987e. eCollection 2023 Jun 15.

DOI:10.1039/d3ra02987e
PMID:37342809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10278589/
Abstract

This study aimed to investigate the potential of polyvinyl alcohol/chitosan nanofibers as a drug delivery system for erythromycin. Polyvinyl alcohol/chitosan nanofibers were fabricated using the electrospinning method and characterized using SEM, XRD, AFM, DSC, FTIR, swelling assessment and viscosity analysis. The drug release kinetics, biocompatibility, and cellular attachments of the nanofibers have been evaluated using release studies and cell culture assays. The results showed that the polyvinyl alcohol/chitosan nanofibers displayed improved drug release and biocompatibility compared to the free drug. The study provides important insights into the potential of polyvinyl alcohol/chitosan nanofibers as a drug delivery system for erythromycin and highlights the need for further investigation into the development of nanofibrous drug delivery systems based on polyvinyl alcohol/chitosan for improved therapeutic efficacy and reduced toxicity. The nanofibers prepared in this approach use less antibiotics, which may be beneficial to the environment. The resulting nanofibrous matrix can be used for external drug delivery applications, such as wound healing or topical antibiotic therapy.

摘要

本研究旨在探究聚乙烯醇/壳聚糖纳米纤维作为红霉素药物递送系统的潜力。采用静电纺丝法制备聚乙烯醇/壳聚糖纳米纤维，并通过扫描电子显微镜（SEM）、X射线衍射（XRD）、原子力显微镜（AFM）、差示扫描量热法（DSC）、傅里叶变换红外光谱（FTIR）、溶胀评估和粘度分析对其进行表征。使用释放研究和细胞培养试验对纳米纤维的药物释放动力学、生物相容性和细胞附着情况进行了评估。结果表明，与游离药物相比，聚乙烯醇/壳聚糖纳米纤维具有更好的药物释放性能和生物相容性。该研究为聚乙烯醇/壳聚糖纳米纤维作为红霉素药物递送系统的潜力提供了重要见解，并强调需要进一步研究基于聚乙烯醇/壳聚糖的纳米纤维药物递送系统的开发，以提高治疗效果并降低毒性。通过这种方法制备的纳米纤维使用较少的抗生素，这可能对环境有益。所得的纳米纤维基质可用于外部药物递送应用，如伤口愈合或局部抗生素治疗。

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2
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Int J Biol Macromol. 2023 Feb 15;228:506-516. doi: 10.1016/j.ijbiomac.2022.12.228. Epub 2022 Dec 24.
3
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5
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7
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