Sakthi Velu Kuppu, Aslam Mohammad, Srinivasan Ramachandran, Somu Prathap, Mohandoss Sonaimuthu
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Centre for Ocean Research, Sathyabama Research Park, Sathyabama Institute of Science and Technology, Chennai 600119, Tamil Nadu, India.
Polymers (Basel). 2025 May 20;17(10):1411. doi: 10.3390/polym17101411.
Nanostructured drug-delivery systems with enhanced therapeutic potential have gained attention in biomedical applications. Here, flufenamic acid (FFA)-loaded chitosan/poly(vinyl alcohol) (CHS/PVA; CSPA)-based electrospun nanofibers were fabricated and characterized for antibacterial, anticancer, and antioxidant activities. The FFA-loaded CSPA (FCSPA) nanofibers were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction (XRD), and differential scanning calorimetry to evaluate their formation process, functional group interactions, and crystallinity. Notably, the average diameter of FCSPA nanofibers decreased with increasing CSPA contents (CSPA-1 to CSPA-3), indicating that FFA addition to CSPA-3 significantly decreased its diameter. Additionally, XRD confirmed the dispersion of FFA within the CSPA amorphous matrix, enhancing drug stability. FCSPA nanofibers exhibited a high swelling ratio (significantly higher than that of the CSPA samples). Biodegradation studies revealed that FCSPA exhibited accelerated weight loss after 72 h, indicating its improved degradation compared with those of other formulations. Furthermore, it exhibited a significantly high drug-encapsulation efficiency, ensuring sustained release. FCSPA nanofibers exhibited excellent antibacterial activity, inhibiting and . Regarding anticancer activity, FCSPA decreased HCT-116 cell viability, highlighting its controlled drug-delivery potential. Moreover, FCSPA demonstrated superior antioxidation, scavenging DPPH free radicals. These findings highlight FCSPA nanofibers as multifunctional platforms with wound-healing, drug-delivery, and tissue-engineering potential.
具有增强治疗潜力的纳米结构药物递送系统在生物医学应用中受到了关注。在此，制备了负载氟芬那酸（FFA）的基于壳聚糖/聚乙烯醇（CHS/PVA；CSPA）的电纺纳米纤维，并对其抗菌、抗癌和抗氧化活性进行了表征。通过扫描电子显微镜、傅里叶变换红外光谱、X射线衍射（XRD）和差示扫描量热法对负载FFA的CSPA（FCSPA）纳米纤维进行了表征，以评估其形成过程、官能团相互作用和结晶度。值得注意的是，FCSPA纳米纤维的平均直径随着CSPA含量的增加（CSPA-1至CSPA-3）而减小，这表明向CSPA-3中添加FFA显著降低了其直径。此外，XRD证实了FFA在CSPA无定形基质中的分散，提高了药物稳定性。FCSPA纳米纤维表现出高溶胀率（显著高于CSPA样品）。生物降解研究表明，FCSPA在72小时后表现出加速失重，表明其与其他制剂相比降解性能有所改善。此外，它表现出显著高的药物包封效率，确保了药物的持续释放。FCSPA纳米纤维表现出优异的抗菌活性，可以抑制……。关于抗癌活性，FCSPA降低了HCT-116细胞的活力，突出了其可控的药物递送潜力。此外，FCSPA表现出卓越的抗氧化性能，能够清除DPPH自由基。这些发现突出了FCSPA纳米纤维作为具有伤口愈合、药物递送和组织工程潜力的多功能平台。
