Michelson J B, Whitcher J P, Wilson S, O'Connor G R
Am J Ophthalmol. 1979 Mar;87(3):278-80. doi: 10.1016/0002-9394(79)90062-x.
A 27-year-old man who was a heroin addict had light flashes in front of the right eye and a hemicentral scotoma immediately after intravenous cocaine. The initial ophthalmoscopic appearance was of a white foreign body lying over the papillomacular bundle of the retina in the right eye. This ophthalmoscopic finding was consistent with intraocular talc, cornstarch, or lactose, common diluting agents that are present in intravenous injections of heroin, cocaine, or methylphenidate hydrochloride, and are known to cause systemic embolic phenomena in chronic drug abusers. This glistening crystal on the surface of the retina changed and evolved into a noninfectious but inflammatory organization of retinal granuloma, in which the foreign body crystal could still be visualized at the apex of the lesion. The anterior and posterior segments of the eye remained free of inflammatory signs throughout the course of the organization of the retinal granuloma.
一名27岁的海洛因成瘾男子在静脉注射可卡因后立即出现右眼闪光和半侧中心暗点。最初的眼底镜检查显示右眼视乳头黄斑束上方有一个白色异物。这种眼底镜检查结果与眼内滑石粉、玉米淀粉或乳糖相符，这些是海洛因、可卡因或盐酸哌甲酯静脉注射中常见的稀释剂，已知会在慢性药物滥用者中引起全身性栓塞现象。视网膜表面的这种闪亮晶体发生变化并演变成视网膜肉芽肿的非感染性但炎症性组织，在病变顶端仍可看到异物晶体。在视网膜肉芽肿组织形成的整个过程中，眼的前段和后段均未出现炎症迹象。
