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经皮胫神经刺激与索利那新治疗绝经后女性急迫性尿失禁

Transcutaneous tibial neurostimulation and Solifenacin in urgent incontinence of postmenopausal women.

作者信息

Radinmehr Hojjat, Radnia Nahid, Tabatabaei Azade, Asadi Mohammad Reza, Rahbar Soulmaz, Talimkhani Ailin, Irani Amin Doosti, Hajvalie Gholam Reza

机构信息

Department of Physiotherapy, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan.

Hamadan University of Medical Sciences. Fatemie Hospital, Hamadan.

出版信息

Eur J Transl Myol. 2023 Jun 20;33(2):11358. doi: 10.4081/ejtm.2023.11358.

Abstract

Symptoms of overactive bladder syndrome (OAB), including urinary incontinence, affect a person's quality of life and cause many personal, social and economic problems. Patients were randomly divided into three groups and received transcutaneous tibial nerve stimulation (cTTNS) with fixed parameters or with variable parameters (vTTNS) and Solifenacin drug. The main outcomes including quality of life questionnaire and OAB score and other secondary outcomes were evaluated before and after treatment for 6 weeks. ANOVA test did not show any significant difference between the three groups in quality of life score (p=0.672), OAB symptom score (p=0.159) and incontinence severity (p=0.422). The t-test demonstrated that the post treatment average quality of life score, OAB score, and incontinence severity were significantly different when compared with before treatment in all three groups (p < 0.05). All three methods were effective in treating symptoms of OAB. However, based on the clinical symptoms, cTTNS is recommended as a preferred and acceptable and safe strategy for the treatment of OAB in women over 50 years old.

摘要

膀胱过度活动症(OAB)的症状,包括尿失禁,会影响人的生活质量,并引发诸多个人、社会和经济问题。患者被随机分为三组,分别接受固定参数的经皮胫神经刺激(cTTNS)、可变参数的经皮胫神经刺激(vTTNS)以及索利那新药物治疗。主要结局包括生活质量问卷、OAB评分以及其他次要结局,在治疗前及治疗6周后进行评估。方差分析测试显示,三组在生活质量评分(p = 0.672)、OAB症状评分(p = 0.159)和尿失禁严重程度(p = 0.422)方面均无显著差异。t检验表明,与治疗前相比,所有三组治疗后的平均生活质量评分、OAB评分和尿失禁严重程度均有显著差异(p < 0.05)。所有三种方法在治疗OAB症状方面均有效。然而,基于临床症状,对于50岁以上女性,cTTNS被推荐作为治疗OAB的首选、可接受且安全的策略。

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