College of Nursing, University of Utah, Salt Lake City, Utah, United States of America.
Department of Health and Kinesiology, University of Utah, Salt Lake City, Utah, United States of America.
PLoS One. 2023 Jun 22;18(6):e0287152. doi: 10.1371/journal.pone.0287152. eCollection 2023.
To determine the feasibility and acceptability of an mHealth, home-based exercise intervention among stage II-III colorectal cancer (CRC) survivors within 5-years post-resection and adjuvant therapy.
This pilot randomized controlled trial of a 12-week mHealth, home-based exercise intervention, randomly assigned CRC survivors to a high-intensity interval training (HIIT) or moderate-intensity continuous exercise (MICE) prescription. The following assessments were carried out at baseline and end-of-study (EOS): handgrip strength, short physical performance battery (SPPB), PROMIS physical function, neuropathy total symptom score-6 (NTSS-6), Utah early neuropathy scale (UENS), cardiopulmonary exercise testing, anthropometrics, and body composition via BOD POD, modified Godin leisure-time activity questionnaire. Feasibility, as defined by number of completed prescribed workouts and rate of adherence to individualized heart rate (HR) training zones, was evaluated at EOS. Acceptability was assessed by open-ended surveys at EOS. Descriptive statistics were generated for participant characteristics and assessment data.
Seven participants were included in this pilot study (MICE: n = 5, HIIT: n = 2). Median age was 39 years (1st quartile: 36, 3rd quartile: 50). BMI was 27.4 kg/m2 (1st quartile: 24.5, 3rd quartile: 29.7). Most participants had stage III CRC (71%, n = 5). We observed an 88.6% workout completion rate, 100% retention rate, no adverse events, and qualitative data indicating improved quality of life and positive feedback related to ease of use, accountability, motivation, and autonomy. Mean adherence to HR training zones was 95.7% in MICE, and 28.9% for the high-intensity intervals and 51.0% for the active recovery intervals in HIIT; qualitative results revealed that participants wanted to do more/work-out harder.
An mHealth, home-based delivered exercise intervention, including a HIIT prescription, among stage II-III CRC survivors' post-resection and adjuvant therapy was tolerable and showed trends towards acceptability.
确定在 II-III 期结直肠癌（CRC）患者术后 5 年内接受辅助治疗后，基于移动医疗（mHealth）的家庭运动干预的可行性和可接受性。
这是一项 mHealth 家庭运动干预的试点随机对照试验，将 CRC 幸存者随机分配到高强度间歇训练（HIIT）或中等强度持续运动（MICE）方案中。在基线和研究结束时（EOS）进行以下评估：握力、短体适能测试（SPPB）、PROMIS 身体功能、神经病变总症状评分-6（NTSS-6）、犹他州早期神经病变量表（UENS）、心肺运动测试、人体测量学和身体成分通过 BOD POD、改良的 Godin 休闲时间活动问卷。在 EOS 时评估可行性，定义为完成规定锻炼的次数和对个性化心率（HR）训练区的依从率。在 EOS 时通过开放式调查评估可接受性。为参与者特征和评估数据生成描述性统计。
本研究纳入了 7 名参与者（MICE：n=5，HIIT：n=2）。中位年龄为 39 岁（1 四分位距：36，3 四分位距：50）。BMI 为 27.4kg/m2（1 四分位距：24.5，3 四分位距：29.7）。大多数参与者患有 III 期 CRC（71%，n=5）。我们观察到 88.6%的锻炼完成率，100%的保留率，无不良事件，定性数据表明生活质量提高，并且对易用性、问责制、动机和自主性的积极反馈。MICE 组的 HR 训练区的平均依从率为 95.7%，HIIT 组的高强度间隔为 28.9%，主动恢复间隔为 51.0%；定性结果表明，参与者希望做更多的运动/更努力地锻炼。
在 II-III 期 CRC 患者术后和辅助治疗后，基于 mHealth 的家庭运动干预，包括 HIIT 处方，是可以耐受的，并显示出可接受性的趋势。
