Department of Physical Therapy, Faculty of Health Sciences, BIO277 Group, University of Granada, Granada, Spain.
Sport and Health Research Center (IMUDs), Granada, Spain.
Phys Ther. 2023 Sep 1;103(9). doi: 10.1093/ptj/pzad070.
The purpose of this study was to examine the feasibility, safety, adherence, and preliminary efficacy of the ATOPE program during radiotherapy (RT) or chemotherapy (CT) for women with breast cancer.
This single-blind, pretest-posttest feasibility study included 38 women with breast cancer at the beginning of their treatment. The ATOPE program consisted of 12 to 18 sessions of a multimodal physical exercise program, prescribed based on daily heart rate variability and clinimetric assessments using the ATOPE+ mHealth system. Overall health was assessed with quality of life, autonomous balance, and body composition, whereas health-related fitness was measured through functional capacity, physical activity levels, and upper and lower limb strength.
The rates of recruitment, retention, and adherence were 52.35, 73.68, and 84.37%, respectively, and the satisfaction rating was 9.2 out of a possible 10 points. The perceived health status change score was 3.83 points, scored on a -5 to 5 point scale. No adverse effects were found. Compliance results showed that the ATOPE+ mHealth system was used on 73.38% of the days, and the Fitbit bracelet (Google, Mountain View, CA, USA) was used on 84.91% of the days. Women stayed physically active 55% of days. Regarding preliminary results, for overall health, the percentage of body fat in the RT group decreased by 1.93%, whereas it increased by 5.03% in the CT group. Lower limb strength increased in the RT group, specifically knee extensor isometric strength (6.07%), isokinetic knee flexors 180 degree/second (1.53%), and isokinetic knee extensors 300 degree/second (4.53%), in contrast with the reductions found in the CT group (11.07, 18.67, and 14.89%, respectively).
The ATOPE program, through nonlinear prescription based on daily monitoring with the ATOPE+ mHealth system, is feasible and safe for application during breast cancer treatment. The results suggest that the overall health can be maintained or even improved regarding most variables.
This study focused on the feasibility, safety, and completion of a physical therapist-led program at early diagnosis for adults with breast cancer. The multimodal, supervised, tailored, nonlinear physical exercise program is feasible and safe, showed a good completion rate, and was able to prevent the quality-of-life deficits that are often triggered by systemic breast cancer treatment. This study highlights the importance of daily morning assessments using the ATOPE+ mHealth system in patients with breast cancer to prescribe nonlinear physical exercise.
本研究旨在探讨 ATOPE 方案在乳腺癌患者放疗（RT）或化疗（CT）期间的可行性、安全性、依从性和初步疗效。
这是一项单盲、前后测试的可行性研究，共纳入 38 名乳腺癌初治患者。ATOP 方案包括 12-18 次基于每日心率变异性和 ATOPE+移动健康系统的临床评估的多模式身体运动方案。整体健康状况通过生活质量、自主平衡和身体成分进行评估，而健康相关体能则通过功能能力、身体活动水平以及上下肢力量进行测量。
招募、保留和依从率分别为 52.35%、73.68%和 84.37%，满意度评分为 10 分制的 9.2 分。感知健康状况变化评分为 3.83 分，评分范围为-5 至 5 分。未发现不良反应。依从性结果显示，ATOP+移动健康系统的使用率为 73.38%，Fitbit 手环（Google，Mountain View，CA，USA）的使用率为 84.91%。女性每天有 55%的时间保持身体活跃。关于初步结果，在整体健康方面，RT 组的体脂百分比下降了 1.93%，而 CT 组则增加了 5.03%。RT 组下肢力量增加，特别是膝关节等速向心收缩强度（6.07%）、膝关节等速 180 度/秒（1.53%）和膝关节等速 300 度/秒（4.53%），而 CT 组则分别下降了 11.07%、18.67%和 14.89%。
基于 ATOPE+移动健康系统的日常监测的非线性处方，ATOP 方案在乳腺癌治疗期间是可行和安全的。结果表明，大多数变量的整体健康状况可以得到维持甚至改善。
本研究侧重于在乳腺癌早期诊断时，由物理治疗师主导的方案的可行性、安全性和完成情况。这种多模式、监督、定制、非线性的身体运动方案是可行和安全的，完成率较高，并且能够防止系统性乳腺癌治疗常引发的生活质量下降。本研究强调了在乳腺癌患者中使用 ATOPE+移动健康系统进行每日清晨评估以制定非线性身体运动方案的重要性。
