Department of Anaesthesiology and Intensive Therapy, 4th Military Clinical Hospital, 50-981 Wroclaw, Poland.
Department of Medical Biochemistry, Wroclaw Medical University, 50-369 Wroclaw, Poland.
Cytokine. 2023 Sep;169:156277. doi: 10.1016/j.cyto.2023.156277. Epub 2023 Jun 20.
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and a syndrome shaped by pathogen and host factors evolving over time. During sepsis, the absolute number of lymphocytes decreases. CD4+ and CD8+ T cells, B cells, and NK cells are reduced. Lymphocytes are an essential element of the body's defence against pathogens. Interleukin 7 has strong anti-apoptotic properties and induces the proliferation of CD4+ and CD8+ T lymphocytes. IL-15 prompts the generation of mature NK cells in the bone marrow, plays an important role in the generation, cytotoxicity, and survival of CD8+ T lymphocytes, and is essential for the survival of natural killer T (NKT) and intestinal intraepithelial lymphocytes (IELs). The study highlights the importance of monitoring IL-7 levels in patients with sepsis and septic shock, as low levels of this cytokine were associated with an increased risk of mortality. Physicians should consider using IL-7 levels as a biomarker to identify patients who are at higher risk of mortality and may require more aggressive treatment.
脓毒症是一种危及生命的器官功能障碍，由宿主对感染的失调反应引起，是一种由病原体和宿主因素随时间演变而成的综合征。在脓毒症中，淋巴细胞的绝对数量减少。CD4+和 CD8+T 细胞、B 细胞和 NK 细胞减少。淋巴细胞是机体抵御病原体的重要组成部分。白细胞介素 7 具有很强的抗凋亡作用，并诱导 CD4+和 CD8+T 淋巴细胞的增殖。IL-15 促使骨髓中成熟 NK 细胞的产生，在 CD8+T 淋巴细胞的生成、细胞毒性和存活中发挥重要作用，对自然杀伤 T（NKT）和肠上皮内淋巴细胞（IEL）的存活至关重要。该研究强调了监测脓毒症和脓毒性休克患者白细胞介素 7 水平的重要性，因为这种细胞因子水平低与死亡率增加相关。医生应考虑将白细胞介素 7 水平用作生物标志物，以识别死亡率较高的患者，这些患者可能需要更积极的治疗。
