Memoli V A, Urban R M, Alroy J, Galante J O
J Orthop Res. 1986;4(3):346-55. doi: 10.1002/jor.1100040311.
The carcinogenic potential of 22 orthopedic prosthetic materials was studied by implantation in bone in Sprague-Dawley rats and evaluated by complete autopsy examination performed at the time of death or at the end of the 30 month experimental period. When the number of malignancies in these rats was compared with control and sham-operated animals, a small increase in sarcomata was observed in animals bearing metal alloy implants containing high contents of cobalt, chromium, or nickel. An increased incidence of lymphomata with bone involvement was also observed in rats bearing metal implants when compared with control and sham-operated animals.
通过将22种骨科假体材料植入斯普拉格-道利大鼠的骨骼中，并在死亡时或30个月实验期结束时进行完整的尸检来研究其致癌潜力。当将这些大鼠中的恶性肿瘤数量与对照动物和假手术动物进行比较时，发现植入含有高含量钴、铬或镍的金属合金假体的动物中肉瘤略有增加。与对照动物和假手术动物相比，植入金属假体的大鼠中伴有骨受累的淋巴瘤发病率也有所增加。
