Christensen B M, LaFond M M
J Parasitol. 1986 Apr;72(2):216-9.
The melanization response against intrathoracically inoculated Brugia pahangi and Dirofilaria immitis microfilariae (mff) isolated from vertebrate host blood was evaluated in both uninfected Aedes aegypti black-eyed Liverpool strain and in mosquitoes harboring a developing B. pahangi infection. The immune response against inoculated mff of either species was significantly reduced by 28-47% in infected as compared with uninfected mosquitoes. Attempts to passively transfer this suppression factor(s) by inoculating naive mosquitoes with 0.1-0.2 microliter of hemolymph from B. pahangi-infected mosquitoes produced equivocal results. The role this parasite-induced immune suppression might play in aiding parasite survival in compatible vectors is discussed.
在未感染的埃及伊蚊黑眼利物浦品系以及携带正在发育的彭亨布鲁线虫感染的蚊子中，评估了针对从脊椎动物宿主血液中分离出的经胸腔接种的彭亨布鲁线虫和犬恶丝虫微丝蚴的黑化反应。与未感染的蚊子相比，感染的蚊子针对接种的任何一种微丝蚴的免疫反应显著降低了28%-47%。通过用0.1-0.2微升来自感染彭亨布鲁线虫的蚊子的血淋巴接种未感染的蚊子来被动转移这种抑制因子的尝试产生了不确定的结果。讨论了这种寄生虫诱导的免疫抑制在帮助寄生虫在相容载体中存活可能发挥的作用。
