Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin Province 133002, China.
Chronic diseases research center, Dalian University College of Medicine, Dalian, Liaoning, 116622, China.
Biomed Pharmacother. 2023 Sep;165:114893. doi: 10.1016/j.biopha.2023.114893. Epub 2023 Jun 21.
Gut microbes constitute the main microbiota in the human body, which can regulate biological processes such as immunity, cell proliferation, and differentiation, hence playing a specific function in intestinal diseases. In recent years, gut microbes have become a research hotspot in the pharmaceutical field. Because of their enormous number, diversity, and functional complexity, gut microbes have essential functions in the development of many digestive diseases. Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease with a complex etiology, the exact cause and pathogenesis are unclear. There are no medicines that can cure IBD, and more research on therapeutic drugs is urgently needed. It has been reported that gut microbes play a critical role in pathogenesis, and there is a tight and complex association between gut microbes and IBD. The dysregulation of gut microbes may be a predisposing factor for IBD, and at the same time, IBD may exacerbate gut microbes' disorders, but the mechanism of interaction between the two is still not well defined. The study of the relationship between gut microbes and IBD is not only important to elucidate the pathogenesis but also has a positive effect on the treatment based on the regimen of regulating gut microbes. This review describes the latest research progress on the functions of gut microbes and their relationship with IBD, which can provide reference and assistance for further research. It may provide a theoretical basis for the application of probiotics, fecal microbiota transplantation, and other therapeutic methods to regulate gut microbes in IBD.
肠道微生物构成了人体主要的微生物群，可调节免疫、细胞增殖和分化等生物过程，因此在肠道疾病中发挥特定作用。近年来，肠道微生物已成为药物领域的研究热点。由于其数量巨大、多样性和功能复杂，肠道微生物在许多消化疾病的发展中具有重要功能。炎症性肠病（IBD）是一种病因复杂的慢性非特异性炎症性疾病，确切的病因和发病机制尚不清楚。目前尚无治愈 IBD 的药物，因此迫切需要更多的治疗药物研究。据报道，肠道微生物在发病机制中起关键作用，肠道微生物与 IBD 之间存在紧密而复杂的关联。肠道微生物的失调可能是 IBD 的一个易感因素，同时 IBD 也可能使肠道微生物的紊乱加重，但两者之间的相互作用机制仍未明确。研究肠道微生物与 IBD 的关系不仅对阐明发病机制具有重要意义，而且基于调节肠道微生物的方案进行治疗也具有积极作用。本综述描述了肠道微生物的功能及其与 IBD 的关系的最新研究进展，可为进一步研究提供参考和帮助。这可能为益生菌、粪便微生物移植和其他调节肠道微生物的治疗方法在 IBD 中的应用提供理论依据。
