微管蛋白使微管成为“微柱”。

Tektin makes a microtubule a "micropillar".

机构信息

State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.

State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China; Human Phenome Institute, Fudan University, Shanghai 200438, China.

出版信息

Cell. 2023 Jun 22;186(13):2725-2727. doi: 10.1016/j.cell.2023.05.018.

DOI:10.1016/j.cell.2023.05.018

PMID:37352832

Abstract

Inside sperm flagella, there are nine doublet microtubules composed of A and B tubules. In this issue of Cell, Leung et al. and Zhou et al. present high-resolution cryo-EM structures of doublet microtubules from mammalian sperms and show unprecedented structures of the A tubules, which are almost entirely occupied with tektin bundles.

摘要

在精子鞭毛内，有由 A 管和 B 管组成的九组双联微管。在本期《细胞》杂志上，梁教授等人和周教授等人展示了哺乳动物精子双联微管的高分辨率冷冻电镜结构，并揭示了 A 管前所未有的结构，该结构几乎完全被坚韧蛋白束占据。