Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.
Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK; NIHR Greater Manchester Patient Safety Translational Research Centre, The University of Manchester, Manchester, UK.
Lancet Child Adolesc Health. 2023 Aug;7(8):544-554. doi: 10.1016/S2352-4642(23)00126-8. Epub 2023 Jun 20.
Self-harm and eating disorders share multiple risk factors, with onset typically during adolescence or early adulthood. We aimed to examine the incidence rates of these psychopathologies among young people in the UK in the 2 years following onset of the COVID-19 pandemic.
We conducted a population-based study using the primary care electronic health records of patients aged 10-24 years in the UK Clinical Practice Research Datalink (CPRD). The observation period was from Jan 1, 2010, to March 31, 2022. We calculated the monthly incidence rates of eating disorders and self-harm according to the first record of each outcome. On the basis of antecedent trends between January, 2010, and February, 2020, negative binomial regression models were fitted to predict monthly incidence rates after the pandemic began in March, 2020. Percentage differences between observed and expected incidence were calculated to indicate changes since the onset of the pandemic, with stratification by sex, age, and deprivation quintile.
The primary care health records of 9 184 712 patients aged 10-24 years (4 836 226 [52·7%] female patients and 4 348 486 [47·3%] male patients; n=1881 general practices) were included for analysis. The incidence rates of eating disorders and self-harm among girls were higher than expected between March 1, 2020, and March 31, 2022. The observed incidence of eating disorders was 42·4% (95% CI 25·7-61·3) higher than expected for girls aged 13-16 years, and 32·0% (13·3-53·8) higher than expected for girls aged 17-19 years, whereas other age groups showed little difference between observed and expected incidence. Similarly, the increase in self-harm incidence was driven by girls aged 13-16 years, for whom the observed incidence was 38·4% (20·7-58·5) higher than expected. By contrast, among boys in all age groups, the incidence rates of eating disorders and self-harm were lower than, or close to, the expected rates. Among boys, the observed incidence of eating disorders was 22·8% (9·2-34·4) lower than expected, and the observed incidence of self-harm was 11·5% (3·6-18·7) lower than expected. The estimated increases in eating disorder and self-harm incidence among girls aged 13-16 years were largely attributable to increases within less deprived communities.
Although causes are uncertain, increased incidence of eating disorder diagnoses and self-harm among teenage girls in the UK during the first 2 years of the COVID-19 pandemic highlight an urgent need for intervention. Early identification of mental health difficulties by primary care clinicians is necessary. Timely access to treatments and sufficient support from general practitioners and mental health services needs to be available to manage presenting problems and to prevent exacerbations of conditions.
National Institute for Health and Care Research.
自残和饮食失调共有的多种风险因素,通常在青少年或成年早期发病。我们旨在调查在新冠大流行开始后的 2 年内,英国年轻人中这些精神病理的发病率。
我们使用英国临床实践研究数据链(CPRD)中 10-24 岁患者的初级保健电子健康记录开展了一项基于人群的研究。观察期从 2010 年 1 月 1 日至 2022 年 3 月 31 日。我们根据每种结局的首次记录计算了饮食失调和自残的每月发病率。根据 2010 年 1 月至 2020 年 2 月的前期趋势,拟合了负二项回归模型来预测新冠大流行开始后(2020 年 3 月)的每月发病率。计算观察到的发病率与预期发病率之间的百分比差异,以指示自大流行开始以来的变化,并按性别、年龄和贫困五分位数进行分层。
分析纳入了 918.4712 万名 10-24 岁患者的初级保健健康记录(483.6226 名[52.7%]女性患者和 4348486 名[47.3%]男性患者;1881 家普通实践)。女孩的饮食失调和自残发病率自 2020 年 3 月 1 日至 3 月 31 日以来一直高于预期。13-16 岁女孩的饮食失调实际发病率比预期高 42.4%(95%CI 25.7-61.3),17-19 岁女孩的实际发病率比预期高 32.0%(13.3-53.8),而其他年龄组的观察发病率与预期发病率相差不大。同样,自我伤害发病率的增加是由 13-16 岁女孩推动的,她们的实际发病率比预期高 38.4%(20.7-58.5)。相比之下,所有年龄组的男孩的饮食失调和自残发病率都低于或接近预期水平。在男孩中,饮食失调的实际发病率比预期低 22.8%(9.2-34.4),自我伤害的实际发病率比预期低 11.5%(3.6-18.7)。13-16 岁女孩饮食失调和自残发病率的估计增加主要归因于贫困程度较低的社区内发病率的增加。
尽管病因尚不确定,但新冠大流行期间英国少女中饮食失调和自残发病率的增加突显了紧急需要干预。初级保健临床医生需要早期识别心理健康问题。需要及时获得治疗,并从全科医生和精神卫生服务机构获得足够的支持,以处理现有问题,并防止病情恶化。
国家卫生与保健研究所。