Shreeshti Uchai, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway, Postbox: 1046, Blindern, 0317 Oslo, Norway
J Nutr Health Aging. 2023;27(6):403-410. doi: 10.1007/s12603-023-1920-2.
Aging is associated with changes in body composition. Excess adiposity among older adults has been linked with metabolic syndromes and aggravated age-associated decline in physical functioning. Few longitudinal studies have explored the association between dual-energy X-ray absorptiometry (DXA)-derived total as well as central adiposity measures and frailty. We examined the association of DXA-derived total and central adiposity with pre-frailty/frailty among Norwegian adults after 8 years of follow-up.
Prospective observational study.
Community-dwelling adults from Tromsø, Norway.
Adiposity was defined by fat mass index (FMI) and visceral adipose tissue (VAT) mass assessed using DXA measures. Frailty status was assessed by low grip strength, slow walking speed, exhaustion, unintentional weight loss and low physical activity level. Pre-frail and frail participants at baseline were excluded. Sex-stratified multivariable logistic regression models were used to investigate the association.
Participants comprised 234 women (mean age 68 years) and 146 men (mean age 69 years) attending the population-based Tromsø Study in 2007-2008 (Tromsø6) and 2015-2016 (Tromsø7). At the end of follow-up, 25.6% of the women and 27.4% of the men were pre-frail/frail. Compared with women in the lowest tertiles, those in the highest tertile of baseline FMI (odds ratio [OR] 4.42, 95% confidence interval [CI] 1.88-10.35) and VAT mass (OR 2.47, 95% CI 1.10-5.50), respectively had higher odds for pre-frailty/frailty at follow-up.
We found a higher likelihood of pre-frailty/frailty in later years among women with general and central adiposity in adulthood, highlighting the importance of preventing excess adiposity for healthy aging.
随着人体成分的变化，衰老与之相关。老年人多余的脂肪与代谢综合征有关，并加重了与年龄相关的身体功能下降。很少有纵向研究探讨双能 X 射线吸收法（DXA）得出的总脂肪量和中央脂肪量测量值与虚弱之间的关系。我们检查了 8 年随访后，挪威成年人中 DXA 得出的总脂肪量和中央脂肪量与前虚弱/虚弱之间的关系。
前瞻性观察性研究。
挪威特罗姆瑟的社区居民。
使用 DXA 测量来定义体脂指数（FMI）和内脏脂肪组织（VAT）质量。虚弱状况通过握力低、步行速度慢、疲惫、非自愿体重减轻和低身体活动水平来评估。排除了基线时虚弱和虚弱的参与者。使用性别分层多变量逻辑回归模型来研究这种关系。
参与者包括参加 2007-2008 年（特罗姆瑟 6 年）和 2015-2016 年（特罗姆瑟 7 年）人口基础特罗姆瑟研究的 234 名女性（平均年龄 68 岁）和 146 名男性（平均年龄 69 岁）。随访结束时，25.6%的女性和 27.4%的男性处于前虚弱/虚弱状态。与最低三分位的女性相比，基线 FMI 最高三分位（优势比 [OR] 4.42，95%置信区间 [CI] 1.88-10.35）和 VAT 质量（OR 2.47，95% CI 1.10-5.50）的女性，在随访时更有可能处于前虚弱/虚弱状态。
我们发现成年后女性的总体和中央肥胖与以后年份出现前虚弱/虚弱的可能性更高，这突出表明了预防肥胖对健康衰老的重要性。
