Fermín-Martínez Carlos A, Ramírez-García Daniel, Antonio-Villa Neftali Eduardo, López-Teros Miriam Teresa, Seiglie Jacqueline A, Pérez Roberto Carlos Castrejón, Peña Carmen García, Gutiérrez-Robledo Luis Miguel, Bello-Chavolla Omar Yaxmehen
Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.
MD/PhD (PECEM) Program, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
medRxiv. 2024 Aug 20:2024.08.20.24312308. doi: 10.1101/2024.08.20.24312308.
Older adults have heterogeneous aging rates. Here, we explored the impact of biological age (BA) and accelerated aging on frailty in community-dwelling older adults.
We assessed 735 community-dwelling older adults from the Coyocan Cohort. BA was measured using AnthropoAge, accelerated aging with AnthropoAgeAccel, and frailty using both Fried's phenotype and the frailty index. We explored the association of BA and accelerated aging (AnthropoAgeAccel ≥0) with frailty at baseline and characterized the impact of both on body composition and physical function. We also explored accelerated aging as a risk factor for frailty progression after 3-years of follow-up.
Older adults with accelerated aging have higher frailty prevalence and indices, lower handgrip strength and gait speed. AnthropoAgeAccel was associated with higher frailty indices (β=0.0053, 95%CI 0.0027-0.0079), and increased odds of frailty at baseline (OR 1.16, 95%CI 1.09-1.25). We observed a sexual dimorphism in body composition and physical function linked to accelerated aging in non-frail participants; however, this dimorphism was absent in pre-frail/frail participants. Accelerated aging at baseline was associated with higher risk of frailty progression over time (OR 1.74, 95%CI 1.11-2.75).
Despite being intertwined, biological accelerated aging is largely independent of frailty in community-dwelling older adults.
老年人的衰老速度存在异质性。在此，我们探讨了生物年龄（BA）和加速衰老对社区居住老年人虚弱的影响。
我们评估了来自科约阿坎队列的735名社区居住老年人。使用AnthropoAge测量BA，使用AnthropoAgeAccel测量加速衰老，并使用Fried表型和虚弱指数评估虚弱。我们探讨了BA和加速衰老（AnthropoAgeAccel≥0）与基线时虚弱的关联，并描述了两者对身体成分和身体功能的影响。我们还探讨了加速衰老作为3年随访后虚弱进展的危险因素。
加速衰老的老年人虚弱患病率和指数更高，握力和步速更低。AnthropoAgeAccel与更高的虚弱指数相关（β=0.0053，95%CI 0.0027-0.0079），并且在基线时虚弱的几率增加（OR 1.16，95%CI 1.09-1.25）。我们在非虚弱参与者中观察到与加速衰老相关的身体成分和身体功能的性别差异；然而，在虚弱前期/虚弱参与者中不存在这种差异。基线时的加速衰老与随时间推移虚弱进展的更高风险相关（OR 1.74，95%CI 1.11-2.75）。
尽管相互交织，但生物加速衰老在很大程度上独立于社区居住老年人的虚弱。
