富含荠蓝油的饼干对老年人血清中 ω-3 脂肪酸组成的影响：一项随机安慰剂对照的初步试验。

The Effect of Crackers Enriched with Camelina Sativa Oil on Omega-3 Serum Fatty Acid Composition in Older Adults: A Randomized Placebo-Controlled Pilot Trial.

机构信息

Alessandra Vincenti, Dietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia; via Bassi 21, 27100 Pavia, Italy, Email address:

出版信息

J Nutr Health Aging. 2023;27(6):463-471. doi: 10.1007/s12603-023-1925-x.

DOI:10.1007/s12603-023-1925-x

PMID:37357331

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10238773/

Abstract

BACKGROUND

Camelina sativa oil is one of the richest dietary sources of omega-3, with polyunsaturated fatty acids amounts of over 50%, linolenic acid content of around 40-45%, and linoleic acid of about 15%. Moreover, this oil is a valuable source of antioxidants which provide oxidative stability. All those features raise interest in considering Camelina oil as an alternative and sustainable oil source providing stable omega-3-rich emulsions for functional food production.

OBJECTIVES

The present study aimed to investigate the effects of Camelina oil-enriched crackers on serum omega-3 concentration, inflammatory markers and serum lipid profile.

DESIGN

Randomized placebo-controlled pilot trial.

SETTING

Research and Development Center (Complife Italia s.r.l.).

PARTICIPANTS

Sixty-six free-living older volunteers (aged≥65 years).

INTERVENTION

Older adults were enrolled and randomly assigned to one of two groups: the camelina group or the placebo group. Subjects consumed daily 35 g of crackers (Camelina enriched crackers or placebo ones) twice daily for 12 weeks.

MEASUREMENTS

Serum polyunsaturated fatty acid profile, inflammatory status and serum lipid panel parameters were recorded pre and post-intervention.

RESULTS

In the camelina group, alpha-linolenic acid serum concentration was significantly higher (p<0.01) compared to the placebo group at the end of the study. Concerning inflammatory plasma markers, a significant mean pro-inflammatory interleukin-18 plasma concentration decrease in the placebo group compared to the camelina one was observed (p<0.05). No significant differences in other mean inflammatory markers concentrations post-intervention were noted in either group. Lastly, examining the change in lipid profile, it is noteworthy that a higher reduction of total cholesterol, low-density lipoprotein and triglycerides in the camelina group post-intervention, despite the lack of statistical significance.

CONCLUSION

Camelina oil significantly elevated the serum alpha-linolenic acid concentration with no significant changes in inflammatory markers and lipid profile.

摘要

背景

荠蓝籽油是ω-3 最丰富的饮食来源之一，其多不饱和脂肪酸含量超过 50%，亚麻酸含量约为 40-45%，亚油酸含量约为 15%。此外，这种油是抗氧化剂的宝贵来源，可提供氧化稳定性。所有这些特征都引起了人们的兴趣，认为荠蓝油是一种替代和可持续的油源，可以为功能性食品生产提供稳定的富含 ω-3 的乳液。

目的

本研究旨在探讨富含荠蓝油的薄脆饼干对血清 ω-3 浓度、炎症标志物和血清脂质谱的影响。

设计

随机安慰剂对照试验。

地点

研究与开发中心（Complife Italia s.r.l.）。

参与者

66 名自由生活的老年人志愿者（年龄≥65 岁）。

干预措施

老年人被招募并随机分为两组：荠蓝组或安慰剂组。受试者每天食用 35 克薄脆饼干（富含荠蓝油的薄脆饼干或安慰剂），每日两次，共 12 周。

测量

记录干预前后血清多不饱和脂肪酸谱、炎症状态和血清脂质谱参数。

结果

在荠蓝组中，与安慰剂组相比，研究结束时血清α-亚麻酸浓度显著升高（p<0.01）。关于炎症的血浆标志物，与荠蓝组相比，安慰剂组的促炎白细胞介素-18 血浆浓度显著降低（p<0.05）。在干预后，两组中其他炎症标志物的平均浓度均无显著差异。最后，检查血脂谱的变化，值得注意的是，尽管荠蓝组的总胆固醇、低密度脂蛋白和甘油三酯在干预后有更高的降低，但没有统计学意义。