Koyama S, Oishi R, Senoh S, Saeki K
Jpn J Pharmacol. 1986 Apr;40(4):527-32. doi: 10.1254/jjp.40.527.
To clarify the histamine (HA) dynamics in peripheral tissues, effects of drugs on the tissue HA and tele-methylhistamine (t-MH) levels were studied in mice. alpha-Fluoromethylhistidine (50 mg/kg, i.p.) significantly decreased the HA level in the stomach, but not in the liver, heart, ileum, submandibular gland and skin of mice. This compound had no significant effect on the t-MH level in any tissue examined. In non-fasted and 24-hr fasted animals, the t-MH level in the liver, heart and ileum was significantly increased by treatment with aminoguanidine (10 mg/kg, i.p.) plus pargyline (65 mg/kg, i.p.). However, in mice fasted for 48 hr, this treatment was ineffective in increasing the t-MH level in the heart and ileum, suggesting that the t-MH level in some peripheral tissues is under the influence of the food intake. Even if HA is synthetized and then metabolized in the peripheral tissues, the size of the HA pool with a rapid turnover in each tissue except for the gastric tissue seems to be very small.
为阐明外周组织中的组胺（HA）动态变化，研究了药物对小鼠组织HA和 tele-甲基组胺（t-MH）水平的影响。α-氟甲基组氨酸（50 mg/kg，腹腔注射）显著降低了小鼠胃中的HA水平，但对肝脏、心脏、回肠、颌下腺和皮肤中的HA水平无影响。该化合物对所检测的任何组织中的t-MH水平均无显著影响。在未禁食和禁食24小时的动物中，用氨基胍（10 mg/kg，腹腔注射）加帕吉林（65 mg/kg，腹腔注射）处理可显著提高肝脏、心脏和回肠中的t-MH水平。然而，在禁食48小时的小鼠中，这种处理对提高心脏和回肠中的t-MH水平无效，这表明某些外周组织中的t-MH水平受食物摄入的影响。即使HA在外周组织中合成然后代谢，除胃组织外，每个组织中周转迅速的HA池的大小似乎非常小。
