Yoshitomi I, Itoh Y, Oishi R, Saeki K
Brain Res. 1986 Jan 1;362(1):195-8. doi: 10.1016/0006-8993(86)91418-6.
When footshock was given to mice at 15-s intervals for 30-120 min, there was a significant increase in the brain level of tele-methyl-histamine (t-MH), a predominant metabolite of brain histamine (HA). This footshock-induced elevation of the t-MH level also occurred in mice pretreated with pargyline but not in mice pretreated with metoprine. The footshock facilitated the HA depletion induced by a-fluoromethylhistidine. These results suggest that footshock increases the brain HA turnover.
