Nakano G, Ritchie J K, Thomson J P
Jpn J Surg. 1986 May;16(3):189-94. doi: 10.1007/BF02471092.
Most patients with ulcerative colitis respond well to medical treatment, however surgical treatment may be required in cases with severe clinical symptoms. We treated eight patients with distal ulcerative colitis (DUC), limited to the rectum and distal sigmoid colon, who were treated at St. Mark's Hospital by excision of the rectum and sigmoid colon with permanent colostomy. Four who did not respond to medical treatment and had severe and intermittent symptoms of long-standing, three with no control of the distressing diarrhea with a shorter history, and those with a severe dysplasia evidenced by rectal biopsy were surgically treated. Two of eight had a recurrence at the proximal colon within 6 and 10 years respectively but responded well to conservative management. From these observations it concluded that the procedure for patients with DUC may be one of adequate operations. Histological features of the resected specimens did not relate to the postoperative outcome of these patients.
大多数溃疡性结肠炎患者对药物治疗反应良好,但对于临床症状严重的病例可能需要手术治疗。我们治疗了8例远端溃疡性结肠炎(DUC)患者,病变局限于直肠和乙状结肠远端,他们在圣马克医院接受了直肠和乙状结肠切除及永久性结肠造口术。其中4例对药物治疗无反应且有长期严重的间歇性症状,3例有较短病史的令人痛苦的腹泻无法控制,以及经直肠活检证实有严重发育异常的患者接受了手术治疗。8例中有2例分别在6年和10年内近端结肠复发,但对保守治疗反应良好。从这些观察结果得出结论,DUC患者的手术方式可能是一种合适的手术。切除标本的组织学特征与这些患者的术后结果无关。