Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
School of Medicine, Nankai University, Tianjin, China.
Int J Colorectal Dis. 2023 Jun 26;38(1):178. doi: 10.1007/s00384-023-04470-1.
Colorectal cancer (CRC) is one of the most common cancers and is associated with high incidence and mortality rates worldwide. CRC has caused a tremendous loss of human health and wealth. The incidence and mortality of colorectal carcinoma are increasing in young adults. Early cancer detection and prevention are made possible through screening. At present, the faecal immunochemical test (FIT) is a noninvasive method that can be used for the large-scale clinical screening of CRC status. Therefore, this study, based on CRC screening results in Tianjin from 2012 to 2020, was conducted to analyse the major differences in diagnostic performance parameters according to sex and age.
This study was based on 39,991 colonoscopies performed for individuals in the Tianjin CRC screening program from 2012 to 2020. Of these individuals, they had complete FIT and colonoscopy results. The differences in FIT results were analysed by sex and age.
According to this study, males were generally more likely to develop advanced neoplasms (ANs) than females, and the prevalence increased with age. Males with negative FIT results were more likely to have advanced neoplasms than females with positive results. The accuracy of the FIT in detecting ANs in each age group was 54.9%, 45.5%, 48.6% and 49.5% in the 40-49, 50-59, 60-69, and ≥ 70 age groups, respectively.
The FIT detected ANs with highest accuracy in the 40-49 age group. Our research can provide guidance to formulate CRC screening strategies.
结直肠癌（CRC）是最常见的癌症之一，在全球范围内具有较高的发病率和死亡率。CRC 给人类健康和财富造成了巨大损失。在年轻人中，结肠癌的发病率和死亡率呈上升趋势。通过筛查可以实现早期癌症的检测和预防。目前，粪便免疫化学试验（FIT）是一种非侵入性方法，可用于 CRC 状态的大规模临床筛查。因此，本研究基于 2012 年至 2020 年天津的 CRC 筛查结果，分析了根据性别和年龄的不同，诊断性能参数的主要差异。
本研究基于 2012 年至 2020 年天津 CRC 筛查计划中进行的 39991 例结肠镜检查，这些个体均有完整的 FIT 和结肠镜检查结果。通过性别和年龄分析 FIT 结果的差异。
根据本研究，男性比女性更易发生晚期肿瘤（ANs），且患病率随年龄增长而增加。FIT 结果为阴性的男性比阳性的女性更易发生晚期肿瘤。FIT 在每个年龄组检测 ANs 的准确性分别为 40-49、50-59、60-69 和≥70 岁年龄组的 54.9%、45.5%、48.6%和 49.5%。
FIT 在 40-49 岁年龄组检测 ANs 的准确性最高。我们的研究可以为制定 CRC 筛查策略提供指导。
