School of Stomatology, Weifang Medical University, Baotong West Street No. 7166, Weifang, Shandong Province, China.
Hum Cell. 2023 Sep;36(5):1620-1637. doi: 10.1007/s13577-023-00943-1. Epub 2023 Jun 26.
Teeth are a kind of masticatory organs of special histological origin, unique to vertebrates, playing an important role in chewing, esthetics, and auxiliary pronunciation. In the past decades, with the development of tissue engineering and regenerative medicine, the studies of mesenchymal stem cells (MSCs) gradually attracted the interest of researchers. Accordingly, several types of MSCs have been successively isolated in teeth or teeth-related tissues, including dental pulp stem cells, periodontal ligament stem cells, stem cells from human exfoliated deciduous teeth, dental follicle stem cells, stem cells from apical papilla and gingival mesenchymal stem cells. These dental stem cells (DSCs) are easily accessible, possess excellent stem cell characteristics, such as high proliferation rates and profound immunomodulatory properties. Small-molecule drugs are widely used and show great advantages in clinical practice. As research progressed, small-molecule drugs are found to have various complex effects on the characteristics of DSCs, especially the enhancement of biological characteristics of DSCs, which has gradually become a hot issue in the field of DSCs research. This review summarizes the background, current status, existing problems, future research directions, and prospects of the combination of DSCs with three common small-molecule drugs: aspirin, metformin, and berberine.
牙齿是一种具有特殊组织学来源的咀嚼器官，是脊椎动物所特有的，在咀嚼、美观和辅助发音方面起着重要作用。在过去几十年中，随着组织工程和再生医学的发展，间充质干细胞（MSCs）的研究逐渐引起了研究人员的兴趣。因此，已经成功地从牙齿或与牙齿相关的组织中分离出几种类型的 MSC，包括牙髓干细胞、牙周膜干细胞、人脱落乳牙干细胞、牙囊干细胞、根尖乳头干细胞和牙龈间充质干细胞。这些牙齿干细胞（DSC）易于获取，具有出色的干细胞特性，如高增殖率和深刻的免疫调节特性。小分子药物在临床实践中被广泛应用，并具有很大的优势。随着研究的进展，小分子药物被发现对 DSC 的特性具有各种复杂的影响，特别是增强 DSC 的生物学特性，这逐渐成为 DSC 研究领域的一个热点问题。本文综述了 DSC 与三种常见的小分子药物（阿司匹林、二甲双胍和小檗碱）联合应用的背景、现状、存在的问题、未来研究方向和前景。
