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羟氯喹视网膜病变的未满足需求与未来展望

Unmet needs and future perspectives in hydroxychloroquine retinopathy.

作者信息

Yusuf Imran H, Charbel Issa Peter, Ahn Seong Joon

机构信息

Oxford Eye Hospital and Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.

出版信息

Front Med (Lausanne). 2023 Jun 9;10:1196815. doi: 10.3389/fmed.2023.1196815. eCollection 2023.

Abstract

Retinopathy is a well-recognized toxic effect of hydroxychloroquine treatment. As hydroxychloroquine retinopathy is potentially a vision-threatening condition, early detection is imperative to minimize vision loss due to drug toxicity. However, early detection of hydroxychloroquine retinopathy is still challenging even with modern retinal imaging techniques. No treatment has been established for this condition, except for drug cessation to minimize further damage. In this perspective article, we aimed to summarize the knowledge gaps and unmet needs in current clinical practice and research in hydroxychloroquine retinopathy. The information presented in this article may help guide the future directions of screening practices and research in hydroxychloroquine retinopathy.

摘要

视网膜病变是羟氯喹治疗一种公认的毒性作用。由于羟氯喹视网膜病变可能会威胁视力,早期检测对于将药物毒性导致的视力丧失降至最低至关重要。然而,即使采用现代视网膜成像技术,早期检测羟氯喹视网膜病变仍具有挑战性。除了停药以尽量减少进一步损害外,尚未确立针对这种情况的治疗方法。在这篇观点文章中,我们旨在总结当前羟氯喹视网膜病变临床实践和研究中的知识空白与未满足需求。本文提供的信息可能有助于指导羟氯喹视网膜病变筛查实践和研究的未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf00/10288184/50d91d2247ef/fmed-10-1196815-g001.jpg

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