Chen Hanxu, Luo Zhiqiang, Lin Xiang, Zhu Yujuan, Zhao Yuanjin
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001 China.
Nano Res. 2023 Apr 26:1-28. doi: 10.1007/s12274-023-5651-9.
As a promising new micro-physiological system, organ-on-a-chip has been widely utilized for pharmaceutical study and tissues engineering based on the three-dimensional constructions of tissues/organs and delicate replication of -like microenvironment. To better observe the biological processes, a variety of sensors have been integrated to realize , real-time, and sensitive monitoring of critical signals for organs development and disease modeling. Herein, we discuss the recent research advances made with respect to sensors-integrated organ-on-a-chip in this overall review. Firstly, we briefly explore the underlying fabrication procedures of sensors within microfluidic platforms and several classifications of sensory principles. Then, emphasis is put on the highlighted applications of different types of organ-on-a-chip incorporated with various sensors. Last but not least, perspective on the remaining challenges and future development of sensors-integrated organ-on-a-chip are presented.
作为一种有前途的新型微生理系统，芯片器官已基于组织/器官的三维构建和类似微环境的精细复制，广泛应用于药物研究和组织工程。为了更好地观察生物过程，已集成了各种传感器，以实现对器官发育和疾病建模的关键信号进行原位、实时和灵敏的监测。在此，我们在这篇综述中讨论了集成传感器的芯片器官的最新研究进展。首先，我们简要探讨了微流控平台内传感器的基本制造工艺以及传感原理的几种分类。然后，重点介绍了结合各种传感器的不同类型芯片器官的突出应用。最后但同样重要的是，还介绍了集成传感器的芯片器官面临的剩余挑战和未来发展前景。
