[Rate of development and the size of the necrotic focus in patients with myocardial infarct treated by intracoronary thrombolysis].

Streptokinase intracoronary thrombolytic therapy (ITT) was given to 68 of 135 patients with large-focal myocardial infarction (MI) admitted to hospital within 6 hours of the attack. Coronary flow was recovered in 31 MI patients. The size of the necrotic focus was assessed on the basis of precordial cartograms from 35 ECG leads and serial measurements of MB CPK activity. ITT achieving successful thrombolysis is conducive to rapid formation and accelerated repair of the necrotic focus in MI patients. The recovery of coronary circulation after 3 hours of infarction was accompanied by the reperfusion syndrome, i. e. rapid necrotization of the ischemized region, a considerable release of MB CPK into the circulation, complex cardiac rhythm and conductivity disorders, and signs of transient heart failure.