Golikov A P, Zingerman L S, Polumiskov V Iu, Berestov A A, Avilova O A
Kardiologiia. 1986 May;26(5):12-7.
Streptokinase intracoronary thrombolytic therapy (ITT) was given to 68 of 135 patients with large-focal myocardial infarction (MI) admitted to hospital within 6 hours of the attack. Coronary flow was recovered in 31 MI patients. The size of the necrotic focus was assessed on the basis of precordial cartograms from 35 ECG leads and serial measurements of MB CPK activity. ITT achieving successful thrombolysis is conducive to rapid formation and accelerated repair of the necrotic focus in MI patients. The recovery of coronary circulation after 3 hours of infarction was accompanied by the reperfusion syndrome, i. e. rapid necrotization of the ischemized region, a considerable release of MB CPK into the circulation, complex cardiac rhythm and conductivity disorders, and signs of transient heart failure.
对135例大面积局灶性心肌梗死（MI）患者中的68例在发病6小时内入院后给予冠状动脉内链激酶溶栓治疗（ITT）。31例MI患者的冠状动脉血流得以恢复。根据35个心电图导联的胸前心电图以及肌酸磷酸激酶（CPK）同工酶MB活性的系列测量结果评估坏死灶的大小。ITT成功溶栓有利于MI患者坏死灶的快速形成和加速修复。梗死3小时后冠状动脉循环的恢复伴有再灌注综合征，即缺血区迅速坏死、大量MB CPK释放入循环、复杂的心律和传导障碍以及短暂性心力衰竭的体征。
