Pavlovic Voja, Ciric Milan, Petkovic Milan, Golubovic Mladjan
Department of Physiology, Medical Faculty University in Nis, Bulevar Dr. Zorana Djindjica 81, 18000 Nis, Serbia.
Department of Physiology, Medical Faculty University in Nis, 18000 Nis, Serbia.
Open Med (Wars). 2023 Jun 22;18(1):20230688. doi: 10.1515/med-2023-0688. eCollection 2023.
In recent years, ascorbic acid (vitamin C) has acquired great interest due to its multiple functions, which results in homeostasis of normal tissues and organs. On the other hand, it has been shown that epigenetic modifications may have an important role in various diseases and therefore are a focus of the extraordinary investigation. Ascorbic acid serves as a cofactor for ten-eleven translocation dioxygenases, which are responsible for deoxyribonucleic acid methylation. Also, vitamin C is required for histone demethylation, since it acts as a cofactor of Jumonji C-domain-containing histone demethylases. It seems that vitamin C may be a mediator between the environment and the genome. The precise and multistep mechanism of ascorbic acid in epigenetic control is still not definitely determined. This article intends to provide the basic and newly discovered functions of vitamin C that are related to epigenetic control. Also, this article will help us to better understand the functions of ascorbic acid and will provide the possible implications of this vitamin in the regulation of epigenetic modifications.
近年来，由于抗坏血酸（维生素C）具有多种功能，可维持正常组织和器官的内环境稳定，因而备受关注。另一方面，研究表明表观遗传修饰可能在多种疾病中发挥重要作用，因此成为了深入研究的焦点。抗坏血酸作为双加氧酶的辅因子，参与DNA甲基化过程。此外，维生素C是组蛋白去甲基化所必需的，因为它作为含Jumonji C结构域的组蛋白去甲基化酶的辅因子发挥作用。维生素C似乎可能是环境与基因组之间的媒介。抗坏血酸在表观遗传调控中的精确多步骤机制仍未完全明确。本文旨在介绍与表观遗传调控相关的维生素C的基本功能和新发现的功能。此外，本文将帮助我们更好地理解抗坏血酸的功能，并为该维生素在表观遗传修饰调控中的潜在作用提供依据。
