He Jiahui, Xu Tangpeng, Zhao Fangrui, Guo Jin, Hu Qinyong
Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Front Genet. 2023 Jun 9;14:1204463. doi: 10.3389/fgene.2023.1204463. eCollection 2023.
Epigenetic regulation plays an important role in the occurrence, development and treatment of tumors. The histone methyltransferase SET-domain-containing 2 (SETD2) plays a key role in mammalian epigenetic regulation by catalyzing histone methylation and interacting with RNA polymerase II to mediate transcription elongation and mismatch repair. As an important bridge between the environment and tumors, SETD2-H3K36me3 plays an important role in the occurrence and development of tumors. Many tumors, including renal cancer, gastric cancer, lung cancer, are closely related to gene mutations. As a key component of common tumor suppressor mechanisms, SETD2-H3K36me3is an important target for clinical disease diagnosis and treatment. Here, we reviewed the structure and function of the and how SETD2-H3K36me3 functions as a bridge between the environment and tumors to provide an in-depth understanding of its role in the occurrence and development of various tumors, which is of great significance for future disease diagnosis and treatment.
表观遗传调控在肿瘤的发生、发展和治疗中起着重要作用。含SET结构域蛋白2（SETD2）作为一种组蛋白甲基转移酶，通过催化组蛋白甲基化以及与RNA聚合酶II相互作用来介导转录延伸和错配修复，在哺乳动物表观遗传调控中发挥关键作用。作为环境与肿瘤之间的重要桥梁，SETD2-H3K36me3在肿瘤的发生和发展中发挥着重要作用。包括肾癌、胃癌、肺癌在内的许多肿瘤都与基因突变密切相关。作为常见肿瘤抑制机制的关键组成部分，SETD2-H3K36me3是临床疾病诊断和治疗的重要靶点。在此，我们综述了SETD2-H3K36me3的结构和功能，以及它如何作为环境与肿瘤之间的桥梁发挥作用，以深入了解其在各种肿瘤发生和发展中的作用，这对未来疾病的诊断和治疗具有重要意义。
