BTBR/J小鼠让我们了解到的关于糖尿病及糖尿病并发症的知识。
What the BTBR/J mouse has taught us about diabetes and diabetic complications.
作者信息
Keller Mark P, Hudkins Kelly L, Shalev Anath, Bhatnagar Sushant, Kebede Melkam A, Merrins Matthew J, Davis Dawn Belt, Alpers Charles E, Kimple Michelle E, Attie Alan D
机构信息
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Department of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
出版信息
iScience. 2023 Jun 7;26(7):107036. doi: 10.1016/j.isci.2023.107036. eCollection 2023 Jul 21.
Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the mutation. We went on to discover that the BTBR- mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model.
人类和小鼠遗传学已经发现了众多致糖尿病基因座，但主要是通过使用动物模型，才对它们导致糖尿病的病理生理基础进行了研究。20多年前，我们偶然发现了一种小鼠品系，它可以作为易肥胖型2型糖尿病的模型，即携带该突变的BTBR（黑褐短尾）小鼠（BTBR T+ Itpr3tf/J，2018）。我们接着发现BTBR小鼠是糖尿病肾病的极佳模型，目前被学术界和制药行业的肾病学家广泛使用。在这篇综述中，我们描述了开发这种动物模型的动机、鉴定出的众多基因，以及从在这个非凡的动物模型中进行的100多项研究所获得的关于糖尿病及其并发症的见解。
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