真菌血清学的发展
Developments in Fungal Serology.
作者信息
White P Lewis
机构信息
Public Health Wales Mycology Reference Laboratory and Cardiff University Centre for Trials Research/Division of Infection and Immunity, UHW, Heath Park, Cardiff, CF14 4XW UK.
出版信息
Curr Fungal Infect Rep. 2023 Apr 13:1-12. doi: 10.1007/s12281-023-00462-4.
PURPOSE OF REVIEW
The true incidence of fungal disease is hampered by conventionally poor diagnostic tests, limited access to advanced diagnostics, and limited surveillance. The availability of serological testing has been available for over two decades and generally underpins the modern diagnosis of the most common forms of fungal disease. This review will focus on technical developments of serological tests for the diagnosis of fungal disease, describing advances in clinical performance when available.
RECENT FINDINGS
Despite their longevity, technical, clinical, and performance limitations remain, and tests specific for fungal pathogens outside the main pathogens are lacking. The availability of LFA and automated systems, capable of running multiple different tests, represents significant developments, but clinical performance data is variable and limited.
SUMMARY
Fungal serology has significantly advanced the diagnosis of the main fungal infections, with LFA availability increasing accessibility to testing. Combination testing has the potential to overcome performance limitations.
综述目的
传统诊断测试不佳、先进诊断手段获取受限以及监测有限，阻碍了真菌病真实发病率的确定。血清学检测已问世二十多年，通常是现代诊断最常见真菌病形式的基础。本综述将聚焦于用于诊断真菌病的血清学检测的技术发展，并在有相关信息时描述其临床性能的进展。
最新发现
尽管血清学检测已存在很长时间，但技术、临床和性能方面仍存在局限性，且缺乏针对主要病原体之外真菌病原体的特异性检测。能够进行多种不同检测的侧向流动分析法（LFA）和自动化系统的出现是重大进展，但临床性能数据参差不齐且有限。
总结
真菌血清学显著推动了主要真菌感染的诊断，LFA的出现增加了检测的可及性。联合检测有可能克服性能限制。
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